Influence of sex on the use of cardiac procedures in patients presenting to the emergency department. A prospective multicenter study.

BACKGROUND

Reports about the use of cardiac procedures have produced conflicting results as to whether there is a sex bias in the use of thrombolytic therapy, cardiac catheterization, or revascularization procedures. The present study was undertaken with the hope of resolving some of these different findings by examining the use of these therapies in women and men who presented to the emergency department with symptoms suggestive of acute cardiac ischemia.

METHODS AND RESULTS

During 7 consecutive months in 1993, 10673 individuals > or = 30 years old who presented with chest pain or other symptoms suggestive of acute cardiac ischemia were enrolled in the Acute Cardiac Ischemia Time-Insensitive Predictive Instrument Clinical Trial at 10 hospitals in the East and Midwest. This study included 2542 patients (24% of all patients) who had confirmed acute myocardial infarction or angina pectoris. There were significant sex differences with respect to demographic and clinical characteristics and the use of cardiac procedures. Among patients with acute myocardial infarction, the use of thrombolytic therapy, cardiac catheterization, and revascularization procedures was similar in women and men after multivariate adjustment. However, in the group with angina pectoris, women were considerably less likely to undergo these procedures, even after adjustment for significant baseline covariates.

CONCLUSIONS

Women with angina pectoris were less likely to undergo cardiac catheterization or revascularization procedures, although unmeasured factors could in part explain the observed differences.