Bolt H M
Institut für Arbeitsphysiologie, Universität Dortmund, Germany.
Toxicology. 1996 Oct 28;113(1-3):356-60. doi: 10.1016/0300-483x(96)03473-7.
Based on the symposium on 1,-3-butadiene and isoprene at Blaine, WA, the following areas need special attention for future research: (1) discrepancies in PBPK modelling by different groups should be solved; (2) potential human target tissues (bone marrow, lymphatic tissues) should be better integrated into PBPK models; (3) the present rapid development in research on human genetic interindividual differences in 1,3-butadiene metabolism and toxicity should be supported, with the intention to determine human subgroups of differential susceptibility and to integrate this into epidemiological research; (4) further validation of past exposures in the epidemiologically studied corhorts is very desirable; (5) the question of possibly differential effects in 1,3-butadiene monomer workers and styrene-butadiene-rubber workers (lymphosarcoma?, reticulosarcoma?, leukemia?) should be resolved in future epidemiological studies; (6) potential human target tissues (bone marrow, lymphatic tissues) should be better integrated into PBPK modelling; (7) risk assessment of isoprene and, by quantitative comparison, of 1,3-butadiene in humans should consider the physiological background of endogenous isoprene production; and (8) future research on biomarkers should establish practical tools for medical surveillance of presently exposed persons.
基于在华盛顿州布莱恩市举行的关于1,3 - 丁二烯和异戊二烯的研讨会，未来研究需要特别关注以下几个方面：（1）不同研究团队在生理药代动力学（PBPK）建模方面的差异应得到解决；（2）潜在的人体靶组织（骨髓、淋巴组织）应更好地整合到PBPK模型中；（3）目前在1,3 - 丁二烯代谢和毒性方面人类基因个体差异研究的快速发展应得到支持，目的是确定易感性不同的人类亚组并将其纳入流行病学研究；（4）非常有必要对流行病学研究队列中过去的暴露情况进行进一步验证；（5）1,3 - 丁二烯单体工人和丁苯橡胶工人中可能存在的差异效应问题（淋巴肉瘤？网状细胞肉瘤？白血病？）应在未来的流行病学研究中得到解决；（6）潜在的人体靶组织（骨髓、淋巴组织）应更好地整合到PBPK建模中；（7）异戊二烯以及通过定量比较1,3 - 丁二烯在人体中的风险评估应考虑内源性异戊二烯产生的生理背景；（8）未来关于生物标志物的研究应建立用于对当前暴露人群进行医学监测的实用工具。
