Herrmann S M, Blanc H, Poirier O, Arveiler D, Luc G, Evans A, Marques-Vidal P, Bard J M, Cambien F
INSERM SC7, 17 Paris, France.
Atherosclerosis. 1996 Oct 25;126(2):299-303. doi: 10.1016/0021-9150(96)05917-5.
Paraoxonase is a high-density-lipoprotein associated enzyme capable of hydrolyzing lipid peroxides, which has been suggested to contribute to atherosclerosis and coronary heart disease (CHD). We studied the Gln/Arg polymorphism affecting codon 192 of human paraoxonase (PON 192) to determine whether this polymorphism, which is associated with serum paraoxonase (PON) activity, represents a risk factor for myocardial infarction (MI). The PON 192 polymorphism was analysed in 642 male patients with myocardial infarction and 701 age-matched controls participating in the ECTIM Study (Etude Cas-Témoins de l'Infarctus du Myocarde). The frequency of the Gln allele was 0.69 in cases and 0.70 in controls (ns). The frequency of the PON 192/Arg allele in 405 MI patients who underwent coronary angiography was 0.295, 0.323 and 0.331, respectively in those with 1, 2 or 3 stenosed arteries (stenosis > 50%) (ns). The mean levels of several plasma lipids, lipoproteins and apolipoproteins were compared between the 3 PON genotypes and no difference was observed. The PON 192 polymorphism was unrelated to MI, the severity of coronary atherosclerosis and to plasma levels of several lipid variables.
对氧磷酶是一种与高密度脂蛋白相关的酶，能够水解脂质过氧化物，有人认为它与动脉粥样硬化和冠心病（CHD）有关。我们研究了影响人对氧磷酶（PON 192）第192位密码子的Gln/Arg多态性，以确定这种与血清对氧磷酶（PON）活性相关的多态性是否代表心肌梗死（MI）的危险因素。在参与ECTIM研究（心肌梗死病例对照研究）的642例男性心肌梗死患者和701例年龄匹配的对照中分析了PON 192多态性。Gln等位基因的频率在病例组中为0.69，在对照组中为0.70（无统计学差异）。在405例接受冠状动脉造影的MI患者中，PON 192/Arg等位基因的频率在有1、2或3条动脉狭窄（狭窄>50%）的患者中分别为0.295、0.323和0.331（无统计学差异）。比较了3种PON基因型之间几种血浆脂质、脂蛋白和载脂蛋白的平均水平，未观察到差异。PON 192多态性与MI、冠状动脉粥样硬化的严重程度以及几种脂质变量的血浆水平无关。
