Chiritescu M M, Chiritescu M E, Scher R K
Department of Medicine, New York Hospital Medical Center of Queens, USA.
Clin Podiatr Med Surg. 1996 Oct;13(4):741-58.
Onychomycosis, the infection of the nail unit by any fungus, far from being just a cosmetic problem, has significant psychological, physical, social, and financial implications. Further, it has experienced a dramatic rise in incidence in recent years. The introduction of newer systemic antifungal drugs (itraconazole, fluconazole, and terbinafine) offer an increased cure rate, a broader spectrum of activity, shortening of the treatment period, and increased safety, compared with the traditional systemic antifungal drugs griseofulvin and ketoconazole. Because the fungi involved are difficult to eradicate from the floors of communal bathing facilities, where the infection is often contracted, an effective treatment is likely to have a significant impact on disease prevalence.
甲癣，即任何真菌对指甲单元的感染，远非只是一个美容问题，它还具有重大的心理、身体、社会和经济影响。此外，近年来其发病率急剧上升。与传统的全身性抗真菌药物灰黄霉素和酮康唑相比，新型全身性抗真菌药物（伊曲康唑、氟康唑和特比萘芬）的引入提高了治愈率，扩大了活性谱，缩短了治疗周期，并提高了安全性。由于感染往往在公共浴室地面发生，而此处涉及的真菌难以根除，有效的治疗可能会对疾病流行率产生重大影响。
