新型疫苗：构建能引发抗肿瘤免疫的病毒。
The new vaccines: building viruses that elicit antitumor immunity.
作者信息
Restifo N P
机构信息
Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Curr Opin Immunol. 1996 Oct;8(5):658-63. doi: 10.1016/s0952-7915(96)80082-3.
Abstract
Whereas cancer cells are poor immunogens, some viruses are capable of eliciting powerful and lifelong immunity. Recombinant viruses and plasmid DNA encoding tumor-associated antigens can elicit powerful and specific immune responses that can be enhanced by the use of cytokines and costimulatory molecules. These immune responses have destroyed growing tumor cells in experimental animal models. For the first time, immunotherapeutic strategies that employ recombinant viruses are being tested in clinical trials with cancer patients.
摘要
癌细胞是弱免疫原，而一些病毒能够引发强大且持久的免疫反应。编码肿瘤相关抗原的重组病毒和质粒DNA可引发强大而特异的免疫反应，利用细胞因子和共刺激分子可增强这些反应。在实验动物模型中，这些免疫反应已摧毁了正在生长的肿瘤细胞。首次采用重组病毒的免疫治疗策略正在癌症患者的临床试验中进行测试。
相似文献
1
The new vaccines: building viruses that elicit antitumor immunity.新型疫苗：构建能引发抗肿瘤免疫的病毒。
Curr Opin Immunol. 1996 Oct;8(5):658-63. doi: 10.1016/s0952-7915(96)80082-3.
2
3
Viral vectors for gene transfer into antigen presenting cells.用于将基因导入抗原呈递细胞的病毒载体。
Curr Opin Mol Ther. 1999 Oct;1(5):558-64.
4
Antitumor vaccination: where we stand.抗肿瘤疫苗接种：我们目前的状况。
Haematologica. 2000 Nov;85(11):1172-206.
5
Strategies for immunotherapy of cancer.癌症免疫治疗策略。
Adv Immunol. 2000;75:235-82. doi: 10.1016/s0065-2776(00)75006-1.
6
Vaccine therapy of established tumors in the absence of autoimmunity.在无自身免疫情况下对已形成肿瘤的疫苗治疗。
Clin Cancer Res. 2003 May;9(5):1837-49.
7
DNA tumor vaccines.DNA肿瘤疫苗
Arch Immunol Ther Exp (Warsz). 2001;49(1):1-11.
8
Recombinant viruses as a tool for therapeutic vaccination against human cancers.重组病毒作为针对人类癌症的治疗性疫苗接种工具。
Immunol Lett. 2000 Sep 15;74(1):11-25. doi: 10.1016/s0165-2478(00)00244-3.
9
Prospects and limitations of recombinant poxviruses for prostate cancer immunotherapy.重组痘病毒用于前列腺癌免疫治疗的前景与局限性
Curr Opin Mol Ther. 1999 Aug;1(4):471-9.
10
Induction of potent antitumor CTL responses by recombinant vaccinia encoding a melan-A peptide analogue.编码黑素-A肽类似物的重组痘苗病毒诱导有效的抗肿瘤CTL反应。
J Immunol. 2000 Jan 15;164(2):1125-31. doi: 10.4049/jimmunol.164.2.1125.
引用本文的文献
1
Influence of tumors on protective anti-tumor immunity and the effects of irradiation.肿瘤对保护性抗肿瘤免疫的影响及放疗的作用。
Front Oncol. 2013 Feb 1;3:14. doi: 10.3389/fonc.2013.00014. eCollection 2013.
2
Immunochemical termination of self-tolerance.自身耐受性的免疫化学终止
Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11276-80. doi: 10.1073/pnas.0804157105. Epub 2008 Aug 6.
3
Molecular cancer vaccines: Tumor therapy using antigen-specific immunizations.分子癌症疫苗：利用抗原特异性免疫的肿瘤治疗。
Pathol Oncol Res. 1997 Sep;3(3):164-76. doi: 10.1007/BF02899917.
4
Escape from immunotherapy: possible mechanisms that influence tumor regression/progression.免疫治疗逃逸：影响肿瘤消退/进展的可能机制
Cancer Immunol Immunother. 2004 Oct;53(10):844-54. doi: 10.1007/s00262-004-0540-x. Epub 2004 Jun 10.
5
Cancer vaccines: progress reveals new complexities.癌症疫苗：进展揭示了新的复杂性。
J Clin Invest. 2002 Aug;110(3):289-94. doi: 10.1172/JCI16216.
6
Creating therapeutic cancer vaccines: notes from the battlefield.开发治疗性癌症疫苗：战场笔记
Trends Immunol. 2001 Jan;22(1):5-7. doi: 10.1016/s1471-4906(00)01793-2.
7
Challenges to the development of antigen-specific breast cancer vaccines.抗原特异性乳腺癌疫苗研发面临的挑战。
Breast Cancer Res. 2001;3(2):95-8. doi: 10.1186/bcr278. Epub 2001 Jan 11.
8
Recombinant yellow fever viruses are effective therapeutic vaccines for treatment of murine experimental solid tumors and pulmonary metastases.重组黄热病病毒是用于治疗小鼠实验性实体瘤和肺转移瘤的有效治疗性疫苗。
J Virol. 2000 Oct;74(19):9197-205. doi: 10.1128/jvi.74.19.9197-9205.2000.
9
The promise of nucleic acid vaccines.核酸疫苗的前景。
Gene Ther. 2000 Jan;7(2):89-92. doi: 10.1038/sj.gt.3301117.
10
Cutting edge: CD4+ T cell control of CD8+ T cell reactivity to a model tumor antigen.前沿：CD4 + T细胞对CD8 + T细胞针对模型肿瘤抗原反应性的调控
J Immunol. 2000 Jan 15;164(2):562-5. doi: 10.4049/jimmunol.164.2.562.
本文引用的文献
1
Highly attenuated modified vaccinia virus Ankara (MVA) as an effective recombinant vector: a murine tumor model.高度减毒的安卡拉痘苗病毒（MVA）作为一种有效的重组载体：小鼠肿瘤模型
Vaccine. 1997 Mar;15(4):387-94. doi: 10.1016/s0264-410x(96)00195-8.
2
Cloning and characterization of the genes encoding the murine homologues of the human melanoma antigens MART1 and gp100.编码人类黑色素瘤抗原MART1和gp100的小鼠同源物的基因的克隆与特性分析。
J Immunother. 1997 Jan;20(1):15-25. doi: 10.1097/00002371-199701000-00002.
3
Vitiligo in patients with melanoma: normal tissue antigens can be targets for cancer immunotherapy.黑色素瘤患者中的白癜风：正常组织抗原可成为癌症免疫治疗的靶点。
J Immunother Emphasis Tumor Immunol. 1996 Jan;19(1):81-4.
4
The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product.一种小鼠结肠肿瘤的免疫显性主要组织相容性复合体I类限制性抗原源自一种内源性逆转录病毒基因产物。
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9730-5. doi: 10.1073/pnas.93.18.9730.
5
Anti-tumor activity of cytotoxic T lymphocytes elicited with recombinant and synthetic forms of a model tumor-associated antigen.用模型肿瘤相关抗原的重组形式和合成形式引发的细胞毒性T淋巴细胞的抗肿瘤活性。
J Immunother Emphasis Tumor Immunol. 1995 Oct;18(3):139-46. doi: 10.1097/00002371-199510000-00001.
6
Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines.共刺激增强重组抗癌疫苗的主动免疫治疗效果。
Cancer Res. 1996 Jun 15;56(12):2832-6.
7
8
Induction of antitumor immunity using bone marrow-generated dendritic cells.利用骨髓生成的树突状细胞诱导抗肿瘤免疫。
J Immunol. 1996 Apr 15;156(8):2918-26.
9
Mutant ras epitopes as targets for cancer vaccines.突变型ras表位作为癌症疫苗的靶点。
Semin Oncol. 1996 Feb;23(1):118-34.
10
Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases.细胞因子增强DNA免疫可有效治疗已形成的肺转移瘤。
J Immunol. 1996 Jan 1;156(1):238-45.
Zotero 插件