McCullough C J, Wheeler M H, Neale M L, Heard G E
Br J Surg. 1977 Feb;64(2):120-4. doi: 10.1002/bjs.1800640210.
This study examines the ability of penicillin to eradicate or modify the pattern of infection in experimental wounds contaminated with Staphylococcus pyrogenes in the presence of chromic catgut or monofilament nylon suture. Penicillin therapy initiated within 4 days of the onset of infection was successful in eradicating infection when compared with untreated controls (P less than 0-01). Infection was modified but not eradicated in penicillin was administered from the seventh day. The response of infection to penicillin was identical in wounds containing monofilament nylon or chromic catgut over a 21-day period. Antibiotics given before wound drainage permitted healing of all chronically infected wounds even in the presence of monofilament nylon. When antibiotics were begun at the time of drainage, wound healing occurred in 50 per cent (P less than 0-01).
本研究检测了在有铬制肠线或单丝尼龙缝线存在的情况下，青霉素清除或改变被化脓性葡萄球菌污染的实验伤口感染模式的能力。与未治疗的对照组相比，在感染开始后4天内开始青霉素治疗成功清除了感染（P小于0.01）。从第7天开始使用青霉素，感染得到改善但未被清除。在21天的时间里，含有单丝尼龙或铬制肠线的伤口对青霉素的反应相同。在伤口引流前给予抗生素，即使存在单丝尼龙，所有慢性感染伤口也能愈合。当在引流时开始使用抗生素时，50%的伤口实现了愈合（P小于0.01）。
