Schapira M, Roquet M E, Henrion J, Ghilain J M, Maisin J M, Heller F
Hôpital de Jolimont, Departement of gastroenterology, Haine-Saint-Paul, Belgium.
Acta Gastroenterol Belg. 1996 Apr-Jun;59(2):168-9.
We report 2 cases of severe nontyphoidal salmonellosis (Salmonella enteritidis), occurring 4 and 5 weeks after starting a treatment with Omeprazole (20 mg a day). No other member of the families was sick, and none of the 2 patients took any meals outside home during the two weeks preceding the first symptoms. Gastric hypochlorhydria is a major risk factor for Salmonella enteritidis, and several cases of severe infection have been described with this condition. After a review of the literature we conclude that patients with diminished gastric acid run an increased risk of developing Salmonella infection and often with a more serious clinical course.
我们报告了2例严重的非伤寒沙门氏菌病（肠炎沙门氏菌），均在开始使用奥美拉唑（每日20毫克）治疗4周和5周后发病。家庭成员中无其他人生病，且两名患者在出现最初症状前两周内均未在户外就餐。胃酸过少是肠炎沙门氏菌感染的主要危险因素，已有多例严重感染病例与此情况相关。在回顾文献后，我们得出结论，胃酸分泌减少的患者发生沙门氏菌感染的风险增加，且临床病程往往更严重。
