The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3-nitrophenyl)acetyl(NP) antibodies.

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作者信息

Imanishi-Kari T, Rajnavölgyi E, Takemori T, Jack R S, Rajewsky K

出版信息

Eur J Immunol. 1979 Apr;9(4):324-31. doi: 10.1002/eji.1830090414.

DOI:10.1002/eji.1830090414

PMID:89036

Abstract

摘要

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The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3-nitrophenyl)acetyl(NP) antibodies.

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Heterogeneous and monoclonal helper T cells induce similar anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibody populations in the primary adoptive response. II. Lambda light chain dominance and idiotope expression.异质性和单克隆辅助性T细胞在初次过继免疫反应中诱导出相似的抗（4-羟基-3-硝基苯基）乙酰（NP）抗体群体。II. λ轻链优势和独特型表达。

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Two major idiotypes in mouse anti-(4-hydroxy-3-nitro-phenyl)acetyl (NP) antibodies are controlled by "allelic" genes.小鼠抗（4-羟基-3-硝基苯基）乙酰（NP）抗体中的两种主要独特型由“等位”基因控制。

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A small hypervariable segment in the variable domain of an immunoglobulin light chain stimulates formation of anti-idiotypic suppressor T cells.免疫球蛋白轻链可变域中的一个小的高变区刺激抗独特型抑制性T细胞的形成。

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