体内抗二硝基苯基抗体应答过程中独特型（Id-460）的表达。I. 将Id-460表达基因定位到免疫球蛋白重链基因座的可变区以及免疫球蛋白κ轻链基因座的可变区。
Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. I. Mapping of genes for Id-460 expression to the variable region of immunoglobulin heavy-chain locus and to the variable region of immunoglobulin kappa-light-chain locus.
作者信息
Dzierzak E A, Janeway C A, Rosenstein R W, Gottlieb P D
出版信息
J Exp Med. 1980 Sep 1;152(3):720-9. doi: 10.1084/jem.152.3.720.
Abstract
The genetic contro of the expression of an idiotype (Id-460) associated with the 2,4-dinitrophenyl (DNP)-binding BALB/c myeloma protein MOPC 460 was studied using congenic strains of mice. It was shown that the expression of high levels of Id-460 during secondary in vivo anti-DNP-ovalbumin responses was determined by genes governing immunoglobulin heavy-chain variable and kappa-light chain variable regions (V kappa). Appropriate alleles at both loci were required for the expression of Id-460. Genes in the major histocompatability complex and the X-linked immune deficiency gene found in strain CBA/N did not greatly affect Id-460 expression. The V kappa gene controlling Id-460 expression can be differentiated from Lyt-3, and it is the first instance in which expression of an idiotype subdivides the V kappa genes associated with the Lyt-3a allele. Although it is likely that the V kappa gene(s) involved are structural, the involvememt of a regulatory gene linked to the structural gene can not be excluded.
摘要
利用同基因系小鼠研究了与2,4-二硝基苯基（DNP）结合的BALB/c骨髓瘤蛋白MOPC 460相关的独特型（Id-460）表达的遗传控制。结果表明，在体内二次抗DNP-卵清蛋白反应期间高水平Id-460的表达由控制免疫球蛋白重链可变区和κ轻链可变区（Vκ）的基因决定。两个位点的合适等位基因对于Id-460的表达都是必需的。主要组织相容性复合体中的基因以及在CBA/N品系中发现的X连锁免疫缺陷基因对Id-460表达影响不大。控制Id-460表达的Vκ基因可与Lyt-3区分开来，这是独特型表达将与Lyt-3a等位基因相关的Vκ基因细分的首个实例。虽然所涉及的Vκ基因很可能是结构基因，但不能排除与结构基因连锁的调控基因的参与。
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Expression of an idiotype (Id-460) during in vivo anti-dinitrophenyl antibody responses. I. Mapping of genes for Id-460 expression to the variable region of immunoglobulin heavy-chain locus and to the variable region of immunoglobulin kappa-light-chain locus.体内抗二硝基苯基抗体应答过程中独特型（Id-460）的表达。I. 将Id-460表达基因定位到免疫球蛋白重链基因座的可变区以及免疫球蛋白κ轻链基因座的可变区。
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引用本文的文献
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J Exp Med. 1981 Nov 1;154(5):1442-54. doi: 10.1084/jem.154.5.1442.
2
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J Exp Med. 1981 Nov 1;154(5):1432-41. doi: 10.1084/jem.154.5.1432.
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A major group of mouse kappa chains controlled by the chromosome 6 locus, IgK-Ef2.由6号染色体位点IgK-Ef2控制的一大组小鼠κ链。
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Cell cooperation during in vivo anti-hapten antibody responses. VI. Evidence for an allogeneic effect replacing one of two helper T cells.体内抗半抗原抗体应答过程中的细胞协作。VI. 同种异体效应替代两个辅助性T细胞之一的证据。
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Absence of an antigen-specific helper T cell required for the expression of the T 15 idiotype in mice treated with anti-mu antibody.在用抗μ抗体处理的小鼠中，表达T15独特型所需的抗原特异性辅助性T细胞缺失。
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Proc Natl Acad Sci U S A. 1970 Nov;67(3):1192-9. doi: 10.1073/pnas.67.3.1192.
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Allogeneic carrier-specific enhancement of hapten-specific secondary B-cell responses.半抗原特异性二次B细胞应答的同种异体载体特异性增强。
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Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.体内抗半抗原抗体反应中的细胞协作。I. 细胞数量对反应的影响。
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Genetic polymorphism of mouse immunoglobulin light chains revealed by isoelectric focusing.等电聚焦揭示的小鼠免疫球蛋白轻链的遗传多态性
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