Suter P M, Maire R, Vetter W
Department of Internal Medicine, Medical Policlinic, University Hospital, Zurich, Switzerland.
J Hypertens. 1995 Dec;13(12 Pt 2):1857-62.
The mechanisms of alcohol-associated hypertension are not known. We tested the hypothesis that the alcohol-associated increase in blood pressure may be caused in part by an alcohol-induced accumulation of abdominal fat.
A total of 842 non-smoking men (mean +/- SD age 52 +/- 16 years) attending the air-show AIR94 in Bouchs, Switzerland, volunteered to participate in a cross-sectional study. Four alcohol consumption frequency categories were self-reported, together with weight changes since the age of 20 and during the last 2 years. Blood pressure, body weight, height and the waist : hip ratio were measured.
The results showed that 83% of the subjects were alcohol-consumers. Systolic (analysis of variance, P = 0.002) and diastolic (P = 0.009) blood pressure and the waist : hip ratio (P>0.0001) increased with increasing alcohol consumption. The self-judged dietary fat intake increased significantly with increasing alcohol consumption. Weight changes over time were positively associated with alcohol consumption. In a regression model alcohol consumption was the fourth most important contributor to systolic and diastolic blood pressure as well as to an increased abdominal fat mass.
The alcohol-associated increase in blood pressure may be caused in part by an alcohol-induced accumulation of abdominal fat. Alcohol consumption favours the development of a positive energy balance and thus the abdominal deposition of fat, which is associated with an increased blood pressure. To reduce the risk of a positive energy balance and the abdominal deposition of fat, the intake of alcohol should be minimized and physical activity increased whenever possible.
酒精相关性高血压的机制尚不清楚。我们检验了这样一个假设，即酒精相关性血压升高可能部分是由酒精诱导的腹部脂肪堆积所致。
共有842名不吸烟男性（平均年龄±标准差为52±16岁）自愿参加了在瑞士布赫举行的AIR94航展上的一项横断面研究。这些男性自我报告了四个饮酒频率类别，以及自20岁以来和过去两年中的体重变化。测量了血压、体重、身高和腰臀比。
结果显示，83%的受试者饮酒。收缩压（方差分析，P = 0.002）、舒张压（P = 0.009）和腰臀比（P>0.0001）均随饮酒量增加而升高。自我判断的膳食脂肪摄入量也随饮酒量增加而显著增加。体重随时间的变化与饮酒量呈正相关。在一个回归模型中，饮酒是收缩压和舒张压以及腹部脂肪量增加的第四大重要影响因素。
酒精相关性血压升高可能部分是由酒精诱导的腹部脂肪堆积所致。饮酒有利于正能量平衡的发展，从而导致腹部脂肪堆积，而这与血压升高有关。为降低正能量平衡和腹部脂肪堆积的风险，应尽量减少酒精摄入量，并尽可能增加体育活动。
