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DNA pooling as a quick method for finding candidate linkages in multigenic trait analysis: an example involving susceptibility to germ cell tumors.

作者信息

Collin G B, Asada Y, Varnum D S, Nadeau J H

机构信息

The Jackson Laboratory, Bar Harbor, Maine 04609, USA.

出版信息

Mamm Genome. 1996 Jan;7(1):68-70. doi: 10.1007/s003359900017.

DOI:10.1007/s003359900017
PMID:8903734
Abstract
摘要

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1
DNA pooling as a quick method for finding candidate linkages in multigenic trait analysis: an example involving susceptibility to germ cell tumors.
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2
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Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross.小鼠自愿摄入乙醇：C57BL/6ByJ与129P3/J F2杂交群体中数量性状基因座及其相互作用的全基因组分析
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Teratoma Development in 129.MOLF-Chr19 Mice Elicits Two Waves of Immune Cell Infiltration.129.MOLF-Chr19小鼠中的畸胎瘤发育引发了两波免疫细胞浸润。
Int J Mol Sci. 2024 Nov 27;25(23):12750. doi: 10.3390/ijms252312750.
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Phenotype and gene signature of testicular tumors in 129.MOLF-Chr19 mice resemble human teratomas.129.MOLF-Chr19小鼠睾丸肿瘤的表型和基因特征类似于人类畸胎瘤。
Andrology. 2025 Jul;13(5):1213-1222. doi: 10.1111/andr.13717. Epub 2024 Jul 29.
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Tumor loci and their interactions on mouse chromosome 19 that contribute to testicular germ cell tumors.

本文引用的文献

1
Spontaneous Testicular Teratomas in an Inbred Strain of Mice.近交系小鼠自发性睾丸畸胎瘤
Proc Natl Acad Sci U S A. 1954 Nov;40(11):1080-7. doi: 10.1073/pnas.40.11.1080.
2
A description of spontaneous congenital testicular teratomas in strain 129 mice.129品系小鼠自发性先天性睾丸畸胎瘤的描述。
J Natl Cancer Inst. 1957 May;18(5):719-47.
3
Familial testicular cancer. What role does heredity play?家族性睾丸癌。遗传因素起到了什么作用？
对小鼠19号染色体上导致睾丸生殖细胞肿瘤的肿瘤基因座及其相互作用。
BMC Genet. 2014 May 30;15:65. doi: 10.1186/1471-2156-15-65.
4
Contrasting effects of Deadend1 (Dnd1) gain and loss of function mutations on allelic inheritance, testicular cancer, and intestinal polyposis.Deadend1（Dnd1）功能获得和功能丧失突变对等位基因遗传、睾丸癌和肠息肉的对比影响。
BMC Genet. 2013 Jun 17;14:54. doi: 10.1186/1471-2156-14-54.
5
Chromosome substitution strains: gene discovery, functional analysis, and systems studies.染色体替换菌株：基因发现、功能分析和系统研究。
Mamm Genome. 2012 Oct;23(9-10):693-705. doi: 10.1007/s00335-012-9426-y. Epub 2012 Sep 8.
6
Bulk segregation mapping of mutations in closely related strains of mice.批量分离近交系小鼠突变的图谱。
Genetics. 2010 Dec;186(4):1139-46. doi: 10.1534/genetics.110.121160. Epub 2010 Oct 5.
7
The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.DM 结构域蛋白 DMRT1 是胎儿生殖细胞增殖和多能性的剂量敏感调节剂。
Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22323-8. doi: 10.1073/pnas.0905431106. Epub 2009 Dec 10.
8
Genetic factors on mouse chromosome 18 affecting susceptibility to testicular germ cell tumors and permissiveness to embryonic stem cell derivation.小鼠18号染色体上影响睾丸生殖细胞肿瘤易感性和胚胎干细胞衍生许可性的遗传因素。
Cancer Res. 2009 Dec 1;69(23):9112-7. doi: 10.1158/0008-5472.CAN-09-3342. Epub 2009 Nov 24.
9
Testicular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain.来自同源染色体置换系129.MOLF-Chr19小鼠品系的睾丸生殖细胞肿瘤易感基因。
Mamm Genome. 2007 Aug;18(8):584-95. doi: 10.1007/s00335-007-9036-2. Epub 2007 Aug 2.
10
Enhancers and suppressors of testicular cancer susceptibility in single- and double-mutant mice.单突变和双突变小鼠睾丸癌易感性的增强子和抑制子
Genetics. 2004 Feb;166(2):925-33. doi: 10.1534/genetics.166.2.925.
Can Fam Physician. 1993 Jul;39:1640-1.
4
Genetic mapping of mutations using phenotypic pools and mapped RAPD markers.
Nucleic Acids Res. 1993 Jun 11;21(11):2697-702. doi: 10.1093/nar/21.11.2697.
5
A mutation in the Ter gene causing increased susceptibility to testicular teratomas maps to mouse chromosome 18.导致对睾丸畸胎瘤易感性增加的Ter基因突变定位于小鼠18号染色体。
Nat Genet. 1994 Apr;6(4):363-8. doi: 10.1038/ng0494-363.
6
The ter primordial germ cell deficiency mutation maps near Grl-1 on mouse chromosome 18.该原始生殖细胞缺陷突变位于小鼠第18号染色体上Grl-1附近。
Mamm Genome. 1994 Jun;5(6):333-6. doi: 10.1007/BF00356550.
7
PCR-amplification of simple sequence repeat variants from pooled DNA samples for rapidly mapping new mutations of the mouse.从混合DNA样本中进行简单序列重复变异的PCR扩增，用于快速定位小鼠的新突变。
Genomics. 1994 Jun;21(3):626-32. doi: 10.1006/geno.1994.1323.
8
Identifying complex disease genes: progress and paradigms.
Nat Genet. 1994 Oct;8(2):108-10. doi: 10.1038/ng1094-108.
9
Mouse chromosome 19.
Mamm Genome. 1994;5 Spec No:S266-75.
10
Use of a DNA pooling strategy to identify a human obesity syndrome locus on chromosome 15.采用DNA池策略鉴定15号染色体上的一种人类肥胖综合征基因座。
Hum Mol Genet. 1995 Jan;4(1):9-13. doi: 10.1093/hmg/4.1.9.