Morrissey J H
Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.
Haemostasis. 1996;26 Suppl 1:66-71. doi: 10.1159/000217243.
Factor VIIa (FVIIa) is the triggering enzyme of the blood clotting cascade in hemostasis and thrombosis and may play an important role in hypercoagulable states. Indeed, certain epidemiologic studies have found elevated FVII coagulant activity to be an independent risk factor for heart disease. However, FVII circulates as the inert zymogen (FVII), the active enzyme (FVIIa), and possibly other forms as well, obscuring the relationship between any specific form of this enzyme and risk of thrombotic disease. New assay techniques based on soluble mutant tissue factor now permit measurement of FVIIa without interference from the large excess of zymogen FVII in plasma. This in turn has enabled direct examination of the role of plasma FVIIa in disease.
凝血因子VIIa（FVIIa）是止血和血栓形成过程中血液凝固级联反应的触发酶，可能在高凝状态中发挥重要作用。事实上，某些流行病学研究发现，FVII凝血活性升高是心脏病的独立危险因素。然而，FVII以无活性的酶原（FVII）、活性酶（FVIIa）以及可能的其他形式循环，这使得该酶的任何特定形式与血栓性疾病风险之间的关系变得模糊不清。基于可溶性突变组织因子的新检测技术现在能够在不受血浆中大量过量酶原FVII干扰的情况下测量FVIIa。这反过来又使得能够直接研究血浆FVIIa在疾病中的作用。
