特非那定与索他洛尔联合使用导致尖端扭转型室性心动过速。

Torsades de pointes from terfenadine and sotalol given in combination.

作者信息

Feroze H, Suri R, Silverman D I

机构信息

Cardiology Division, John Dempsey Hospital, University of Connecticut Health Center, Farmington 06030, USA.

出版信息

Pacing Clin Electrophysiol. 1996 Oct;19(10):1519-21. doi: 10.1111/j.1540-8159.1996.tb03169.x.

DOI:10.1111/j.1540-8159.1996.tb03169.x

PMID:8904547

Abstract

A patient receiving sotalol developed recurrent torsades de pointes following the addition of terfenadine (Seldane) to her medical regimen. A 71-year-old woman with a history of atrial fibrillation successfully suppressed with sotalol, 80 mg bid, was started on terfenadine, 60 mg bid. Eight days later, she developed repeated self-terminating episodes of torsades de pointes. Sotalol and terfenadine were discontinued, and no further arrhythmia was observed after 72 hours of temporary pacing was discontinued.

摘要

一名正在服用索他洛尔的患者，在其药物治疗方案中加用特非那定（赛特赞）后出现了复发性尖端扭转型室速。一名71岁有房颤病史的女性，服用索他洛尔（80毫克，每日两次）成功控制病情，后开始服用特非那定（60毫克，每日两次）。八天后，她出现了反复的、自行终止的尖端扭转型室速发作。停用了索他洛尔和特非那定，在临时起搏72小时停止后未观察到进一步的心律失常。