León-Velarde F, Vargas M, Monge-C C, Torrance R W, Robbins P A
Departamento de Ciencias Fisiológicas, Universidad Peruana Cayetano Heredia, Lima, Peru.
J Appl Physiol (1985). 1996 Oct;81(4):1605-9. doi: 10.1152/jappl.1996.81.4.1605.
This study was designed to determine whether subjects born at high altitude (HA; 2,000 m or above) who subsequently move to near sea level (SL) develop end-tidal PCO2 (PETCO2) and PO2 (PETO2) values that equal those of SL natives living near SL. A total of 108 male HA natives living near SL were identified by survey of a district in Lima, Peru, and a further 108 male SL natives from the same district were identified as control subjects. Of these subjects, satisfactory data for inclusion in the study were obtained from 93 HA and 82 SL subjects. Mean PETCO2 and PETO2 values were 37.7 +/- 2.5 (SD) and 104.7 +/- 3.2 Torr, respectively, in HA subjects and 37.7 +/- 2.2 and 104.8 +/- 3.0 Torr, respectively, in SL subjects. The average difference between SL natives and HA natives for PETCO2 was 0.07 Torr (-0.64 to 0.78; 95% confidence interval) and for PETO2 was 0.05 Torr (-0.89 to 0.99, 95% confidence interval). The average age and weight of the SL and HA subjects did not differ, but the HA subjects were shorter and tended to have larger vital capacities, consistent with their origin at HA. We conclude that the PETCO2 and PETO2 near SL of SL natives and HA natives do not differ.
本研究旨在确定出生于高海拔地区（HA；海拔2000米及以上）、随后迁至近海平面（SL）的受试者，其呼气末二氧化碳分压（PETCO2）和氧分压（PETO2）值是否与生活在近海平面的SL本地居民相同。通过对秘鲁利马一个地区的调查，共识别出108名居住在近海平面的HA男性本地人，并将来自同一地区的另外108名SL男性本地人作为对照受试者。在这些受试者中，从93名HA受试者和82名SL受试者获得了纳入研究的满意数据。HA受试者的平均PETCO2和PETO2值分别为37.7±2.5（标准差）和104.7±3.2托，SL受试者的平均PETCO2和PETO2值分别为37.7±2.2和104.8±3.0托。SL本地人与HA本地人之间PETCO2的平均差异为0.07托（-0.64至0.78；95%置信区间），PETO2的平均差异为0.05托（-0.89至0.99，95%置信区间）。SL和HA受试者的平均年龄和体重没有差异，但HA受试者较矮，肺活量往往较大，这与他们来自高海拔地区的背景一致。我们得出结论，SL本地人和HA本地人在近海平面时的PETCO2和PETO2没有差异。
