食物摄入量和剂量水平会影响盐酸二甲双胍在人体中的吸收，但片剂与溶液剂型不会对此产生影响。
Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.
作者信息
Sambol N C, Brookes L G, Chiang J, Goodman A M, Lin E T, Liu C Y, Benet L Z
机构信息
Department of Biopharmaceutical Sciences, University of California, San Francisco 94143-0446, USA.
出版信息
Br J Clin Pharmacol. 1996 Oct;42(4):510-2. doi: 10.1111/j.1365-2125.1996.tb00017.x.
The pharmacokinetics of four single-dose treatments of the metformin administered orally (as the HCl salt) were compared in 24 healthy subjects: 500 mg and 850 mg tablets and 850 mg solution fasting and 850 mg tablet with food. Solution and tablet formulations are bioequivalent. Bioavailability of a 500 mg tablet is 14% greater than that of an 850 mg tablet. Compared with the fasting state, bioavailability is 24% lower, and the peak concentration delayed about 37 min when an 850 mg tablet is administered with food.
在24名健康受试者中比较了口服（盐酸盐形式）二甲双胍的四种单剂量治疗的药代动力学：500毫克和850毫克片剂、空腹服用的850毫克溶液以及与食物同服的850毫克片剂。溶液和片剂制剂具有生物等效性。500毫克片剂的生物利用度比850毫克片剂高14%。与空腹状态相比，当850毫克片剂与食物同服时，生物利用度降低24%，且达峰浓度延迟约37分钟。
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