Maruff P, Pantelis C, Danckert J, Smith D, Currie J
Neurophysiology and Neurovisual Research Unit, Mental Health Research Institute of Victoria, Parkville, Australia.
Neuropsychologia. 1996 Nov;34(11):1079-84. doi: 10.1016/0028-3932(96)00035-8.
In patients with schizophrenia, abnormal performance on the antisaccade task suggests that for overt attentional shifts, there is difficulty with the endogenous modes have opposite goals. We examined whether patients with schizophrenia also have difficulty with the endogenous control of exogenous orienting when endogenous and exogenous control of exogenous orienting for covert shifts of attention. Fifteen medicated patients with chronic schizophrenia and 15 matched controls performed two versions of the covert orienting of attention task (COVAT). On one COVAT, targets appeared at the cued location (TAC) on all trials. On the second COVAT, targets appeared at the contralateral location to the cue (TCC) on all trials. Reaction time (RT) for TAC and TCC trials was equal in the control group. However, for the schizophrenia group, RT for TCC trials was significantly slower than RT for TAC trials. This indicates that patients with schizophrenia were unable to inhibit the orienting of attention to peripheral cues even when they knew that targets would never appear at the same location as the cue. These results suggest that patients with chronic schizophrenia have difficulty utilizing the endogenous strategies to inhibit exogenous covert attentional shifts.
在精神分裂症患者中，反扫视任务的异常表现表明，对于明显的注意力转移，内源性模式存在相反目标的困难。我们研究了精神分裂症患者在注意力隐蔽转移的外源性定向的内源性控制方面是否也存在困难，此时外源性定向的内源性和外源性控制同时存在。15名患有慢性精神分裂症的服药患者和15名匹配的对照组完成了两个版本的注意力隐蔽定向任务（COVAT）。在一个COVAT中，所有试验的目标都出现在提示位置（TAC）。在第二个COVAT中，所有试验的目标都出现在与提示相对的位置（TCC）。对照组中TAC和TCC试验的反应时间（RT）相等。然而，对于精神分裂症组，TCC试验的RT明显慢于TAC试验。这表明，即使精神分裂症患者知道目标永远不会出现在与提示相同的位置，他们也无法抑制对外周提示的注意力定向。这些结果表明，慢性精神分裂症患者在利用内源性策略抑制外源性隐蔽注意力转移方面存在困难。
