苯妥英治疗后发生的EB病毒阳性非霍奇金淋巴瘤。

EBV-positive non-Hodgkin's lymphoma developing after phenytoin therapy.

作者信息

Garcia-Suarez J, Dominguez-Franjo P, Del Campo F, Herrero B, Munoz M A, Piris M A, Pardo A

机构信息

Department of Haematology, Principe de Asturias University Hospital, Alcalá de Henares, Madrid, Spain.

出版信息

Br J Haematol. 1996 Nov;95(2):376-9. doi: 10.1046/j.1365-2141.1996.d01-1905.x.

DOI:10.1046/j.1365-2141.1996.d01-1905.x

PMID:8904896

Abstract

We report the first case of Epstein Barr virus (EBV) positive non-Hodgkin's lymphoma occurring 20 years after continuous phenytoin therapy for idiopathic epilepsy. This malignant lymphoproliferative disease was preceded by an phenytoin-associated benign reactive lymphadenopathy. Serological findings suggested a chronic active EBV infection. Immunohistochemistry showed that neoplastic cells expressed B antigens (CD20, lambda) and the bcl-2 protein. The presence of EBV-encoded latent membrane protein 1 (LMP 1) was also expressed on neoplastic cells. Cytotoxic chemotherapy (CHOP) reversed the non-Hodgkin's lymphoma.

摘要

我们报告首例在因特发性癫痫接受苯妥英持续治疗20年后发生的爱泼斯坦-巴尔病毒（EBV）阳性非霍奇金淋巴瘤病例。这种恶性淋巴增殖性疾病之前存在苯妥英相关的良性反应性淋巴结病。血清学检查结果提示慢性活动性EBV感染。免疫组织化学显示肿瘤细胞表达B抗原（CD20、λ）和bcl-2蛋白。肿瘤细胞上也表达了EBV编码的潜伏膜蛋白1（LMP 1）。细胞毒性化疗（CHOP方案）使非霍奇金淋巴瘤病情得到缓解。