Ditscherlein G
Institut für Pathologie der Charité, Humboldt-Universität Berlin, Germany.
Clin Nephrol. 1996 Oct;46(4):256-8.
A short survey is given on important pathomorphologic renal lesions in diabetics, particularly diabetic glomerulosclerosis including aspects on the development of its alterations. The frequency of renal complications in autopsy material of 400 diabetics is reported as well as the occurrence of typical and atypical lesions in a series of 267 biopsy specimens from diabetic patients. In about 60% of this biopsy series semithin sections with silver staining and/or immunohistology could be used which allowed a much more precise diagnosis including the recognition of atypical lesions in diabetics, e.g. glomerulonephritis and the combination of glomerulosclerosis and glomerulonephritis. Therefore, the necessity to apply additional morphological techniques in biopsy material is emphasized.
本文简要综述了糖尿病患者重要的肾脏病理形态学病变，特别是糖尿病肾小球硬化症，包括其病变发展的相关方面。报告了400例糖尿病患者尸检材料中肾脏并发症的发生率，以及267例糖尿病患者活检标本中典型和非典型病变的发生情况。在该活检系列中，约60%的标本可采用银染色和/或免疫组织学的半薄切片，这使得诊断更加精确，包括识别糖尿病患者的非典型病变，如肾小球肾炎以及肾小球硬化症与肾小球肾炎的合并症。因此，强调了在活检材料中应用其他形态学技术的必要性。
