Behne D, Gessner H, Kyriakopoulos A
Hahn-Meitner-Institut Berlin, Department Trace Elements in Health and Nutrition, Germany.
J Trace Elem Med Biol. 1996 Sep;10(3):174-9. doi: 10.1016/S0946-672X(96)80029-0.
The suitability of the selenium concentrations in blood plasma, red blood cells, hair and nails to serve as indicators for the selenium status in the main body pools and for the chemical forms of the element ingested was investigated in an animal model. Selenium-deficient male rats, fed a methionine-supplemented low selenium diet, were replenished over a period of 3 months by repeated oral administration of 75Se-labeled sodium selenite or L-selenomethionine in amounts equivalent to the intake from diets with selenium concentrations of 0.3 mg/kg and 2 mg/kg. As the tracer was found to reflect the selenium distribution in the main compartments, quantitative selenium analysis in whole body, liver, skeletal muscle, heart and the monitor materials in the four groups was carried out by measuring the 75Se activity. The blood selenium level was the most suitable parameter for assessing the selenium status in the liver, while the nail selenium concentration was most suited for whole body, skeletal muscle and heart. The differences in the amount and chemical form of dietary selenium were best reflected by the ratios of the selenium levels in hair and plasma or in nails and plasma. The results suggest that with adequate or high selenium intake it might be possible to obtain information on the selenium status of the main body compartments by evaluating the selenium concentrations in several appropriate monitor materials.
在动物模型中，研究了血浆、红细胞、头发和指甲中的硒浓度作为主体库中硒状态指标以及所摄入元素化学形态指标的适用性。给缺硒雄性大鼠喂食补充蛋氨酸的低硒饮食，在3个月的时间里，通过反复口服相当于硒浓度为0.3 mg/kg和2 mg/kg的饮食摄入量的75Se标记的亚硒酸钠或L-硒代蛋氨酸进行补充。由于发现示踪剂能反映硒在主要器官中的分布情况，通过测量75Se活性对四组大鼠的全身、肝脏、骨骼肌、心脏及监测材料进行了定量硒分析。血硒水平是评估肝脏中硒状态的最合适参数，而指甲中的硒浓度最适合用于评估全身、骨骼肌和心脏的硒状态。头发与血浆或指甲与血浆中硒水平的比值最能反映饮食中硒含量和化学形态的差异。结果表明，在摄入充足或高剂量硒的情况下，通过评估几种合适的监测材料中的硒浓度，有可能获得有关主体器官硒状态的信息。
