Ojeda María Luisa, Vázquez Beatriz, Nogales Fátima, Murillo María Luisa, Carreras Olimpia
Department of Physiology and Zoology, Faculty of Pharmacy, Seville University, Seville, Spain.
Int J Environ Res Public Health. 2009 Aug;6(8):2139-49. doi: 10.3390/ijerph6082139. Epub 2009 Jul 30.
Ethanol consumption affects maternal nutrition, the mothers' antioxidant balance and the future health of their progeny. Selenium (Se) is a trace element cofactor of the enzyme glutathione peroxidase (GPx). We will study the effect of ethanol on Se bioavailability in dams and in their progeny. We have used three experimental groups of dams: control, chronic ethanol and pair-fed; and three groups of pups. Se levels were measured by graphite-furnace atomic absorption spectrometry. Serum and hepatic GPx activity was determined by spectrometry. We have concluded that ethanol decreased Se retention in dams, affecting their tissue Se deposits and those of their offspring, while also compromising their progeny's weight and oxidation balance. These effects of ethanol are caused by a reduction in Se intake and a direct alcohol-generated oxidation action.
乙醇摄入会影响母体营养、母亲的抗氧化平衡及其后代的未来健康。硒（Se）是谷胱甘肽过氧化物酶（GPx）的微量元素辅因子。我们将研究乙醇对母鼠及其后代中硒生物利用度的影响。我们使用了三组母鼠实验对象：对照组、慢性乙醇组和配对喂养组；以及三组幼崽。通过石墨炉原子吸收光谱法测量硒水平。通过光谱法测定血清和肝脏中的GPx活性。我们得出的结论是，乙醇会降低母鼠体内的硒保留量，影响其组织和后代的硒沉积，同时还会损害其后代的体重和氧化平衡。乙醇的这些影响是由硒摄入量减少和酒精直接产生的氧化作用引起的。
