Sjölund K F, Sollevi A, Segerdahl M, Hansson P, Lundeberg T
Department of Anaesthesiology and Intensive Care, Karolinska Institutet/ Hospital, Stockholm, Sweden.
Neuroreport. 1996 Jul 29;7(11):1856-60. doi: 10.1097/00001756-199607290-00034.
The aim of the present study was to investigate the effect of intravenous or intrathecal (i.t.) administration of R-phenylisopropyladenosine (R-PIA), a selective A1 adenosine receptor agonist, on spontaneous scratching behaviour, a phenomenon presumably related to pain in a mononeuropathy model (sciatic nerve ligation) in rats. The acute effect of daily i.t. R-PIA injections was studied up to 21 days following nerve ligation. The results demonstrate that both i.v. (30 nmol) and i.t. (3 nmol) R-PIA, in doses not producing any motor impairment, significantly reduces scratching behaviour in this animal model. The mechanism of action for this presumed antinociceptive effect is suggested to occur at the spinal cord level.
本研究的目的是探讨静脉内或鞘内注射选择性A1腺苷受体激动剂R-苯异丙基腺苷（R-PIA）对大鼠单神经病变模型（坐骨神经结扎）中自发搔抓行为的影响，该现象可能与疼痛有关。在神经结扎后长达21天的时间里研究了每日鞘内注射R-PIA的急性效应。结果表明，静脉注射（30 nmol）和鞘内注射（3 nmol）R-PIA，在不产生任何运动障碍的剂量下，均可显著减少该动物模型中的搔抓行为。这种推测的抗伤害感受作用的作用机制被认为发生在脊髓水平。
