Sjölund K F, von Heijne M, Hao J X, Xu X J, Sollevi A, Wiesenfeld-Hallin Z
Department of Anesthesiology and Intensive Care, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
Neurosci Lett. 1998 Feb 27;243(1-3):89-92. doi: 10.1016/s0304-3940(98)00092-5.
Effects of intrathecally (i.t.) administered R-phenylisopropyl adenosine (R-PIA), an adenosine A1 receptor agonist, on presumed pain behaviour were assessed in a rat model of chronic central pain. Spinal cord injury was induced photochemically via laser irradiation of the spinal cord after intravenous injection of erythrosin B in rats. The chronic allodynia-like behaviour that developed in some animals was studied. R-PIA (3 and 10 nmol), injected i.t. reduced the mechanical and cold allodynia-like symptoms as tested with von Frey filaments and ethyl-chloride spray, respectively. No side effects were observed. The effect of R-PIA was significant for up to 5 h and was reversed by theophylline, an adenosine receptor antagonist.
在慢性中枢性疼痛大鼠模型中，评估了鞘内注射腺苷A1受体激动剂R-苯异丙基腺苷（R-PIA）对假定疼痛行为的影响。通过在大鼠静脉注射赤藓红B后对脊髓进行激光照射，以光化学方式诱导脊髓损伤。研究了一些动物出现的慢性痛觉过敏样行为。鞘内注射R-PIA（3和10 nmol）分别降低了用von Frey细丝和氯乙烷喷雾剂测试的机械性和冷痛觉过敏样症状。未观察到副作用。R-PIA的作用长达5小时显著，且被腺苷受体拮抗剂茶碱逆转。
