Lahti R A, Roberts R C, Conley R R, Cochrane E V, Mutin A, Tamminga C A
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA.
Neuroreport. 1996 Aug 12;7(12):1945-8. doi: 10.1097/00001756-199608120-00016.
The density of the presumed dopamine D4 receptor ([3H]YM-09151-2 minus [3H]raclopride), as well as the densities of the two ligands themselves were compared in various areas of cerebral tissue from normal versus schizophrenic subjects off or on antipsychotic drugs at the time of death. Using autoradiographic techniques, and analyzing various brain areas, no differences were found in the density of the D4 receptor, nor were differences found between the groups, in any brain region, in the amount of bound [3H]YM-09151-2 or [3H]raclopride. There were, therefore, no differences in the density of the D3-type receptors, including the D4 receptor, in normal and schizophrenic subjects off or on antipsychotic drugs at the time of death.
在死亡时停用或服用抗精神病药物的正常受试者与精神分裂症受试者的不同脑组织区域中，比较了假定的多巴胺D4受体（[3H]YM-09151-2减去[3H]雷氯必利）的密度，以及两种配体本身的密度。使用放射自显影技术并分析不同脑区，未发现D4受体密度存在差异，在任何脑区中，两组之间在结合的[3H]YM-09151-2或[3H]雷氯必利的量上也未发现差异。因此，在死亡时停用或服用抗精神病药物的正常受试者与精神分裂症受试者中，包括D4受体在内的D3型受体密度没有差异。
