Boissière F, Pradier L, Delaère P, Faucheux B, Revah F, Brice A, Agid Y, Hirsch E C
INSERM U289, Hôpital de la Salpêtrière, Paris, France.
Neuroreport. 1996 Aug 12;7(12):2021-5. doi: 10.1097/00001756-199608120-00034.
Presenilin 2 (STM2) is a recently cloned gene involved in some forms of early onset Alzheimer's disease with autosomal dominant inheritance. Here we report the regional and cellular distribution of STM2 mRNA in the normal human central nervous system. Using in situ hybridization. STM2 gene expression was shown to be confined exclusively to neurones in the central nervous system. A high level of STM2 mRNA expression was observed in the cerebral cortex and the hippocampus, more particularly on pyramidal neurones of Ammon's horn and granular neurones of the dentate gyrus. STM2 mRNA was also detected in Purkinje cells and granular cells of the cerebellum, and in neurones of the striatum and the nucleus basalis of Meynert. Taken together, these results suggest that the expression of STM2 mRNA is not restricted to the neuronal populations that are known to degenerate in Alzheimer's disease.
早老素2（STM2）是最近克隆出的一个基因，与某些常染色体显性遗传的早发性阿尔茨海默病有关。在此，我们报告STM2 mRNA在正常人类中枢神经系统中的区域和细胞分布。运用原位杂交技术，结果显示STM2基因表达仅局限于中枢神经系统的神经元。在大脑皮层和海马体中观察到STM2 mRNA的高水平表达，尤其是在海马角的锥体细胞和齿状回的颗粒细胞中。在小脑的浦肯野细胞和颗粒细胞以及纹状体和迈内特基底核的神经元中也检测到了STM2 mRNA。综上所述，这些结果表明STM2 mRNA的表达并不局限于已知在阿尔茨海默病中会退化的神经元群体。
