Quarteronet D, Pradier L, Czech C, Delalonde L, Burgevin M C, Doble A, Petitet F
Rhône-Poulenc Rorer, Biology/Neurochemistry, CRVA, Vitry sur Seine, France.
Neuroreport. 1996 Nov 4;7(15-17):2587-91. doi: 10.1097/00001756-199611040-00036.
We examined the regional and cellular distribution of presenilin-1 gene expression in the rat brain by in situ hybridization. Microscopic analysis demonstrated that presenilin-1 mRNA is predominantly expressed in areas such as the occipital cortex, the pyramidal layer of the hippocampus, thalamic nuclei and the cerebellar granular layer. The expression of presenilin-1 is mostly neuronal: only a weak hybridization signal was found in the corpus callosum and in the astrocytoma cell lines U373MG and U138MG.
我们通过原位杂交技术研究了早老素-1基因在大鼠脑中的区域和细胞分布。显微镜分析表明，早老素-1信使核糖核酸主要表达于枕叶皮质、海马锥体层、丘脑核以及小脑颗粒层等区域。早老素-1的表达主要在神经元中：仅在胼胝体以及星形细胞瘤细胞系U373MG和U138MG中发现微弱的杂交信号。
