磷脂。XXVII. 饱和与不饱和L-α-卵磷脂的膦酸类似物的合成。
Phosphonolipids. XXVII. Synthesis of phosphonic acid analogs of saturated and unsaturated L-alpha-lecithins.
作者信息
Robinson R, Baer E
出版信息
Can J Biochem. 1977 Aug;55(8):907-10. doi: 10.1139/o77-134.
DOI:10.1139/o77-134
PMID:890584
Abstract
A procedure for the synthesis of saturated and unsaturated phosphonolecithin from the cadmium chloride complex of sn-glycerol-3-(2-trimethylammoniumethyl)-phosphonate is reported. The phosphonolecithins are obtained by acylating sn-glycerol-3(2-trimethylammoniumethyl)-phosphonate-cadmium chloride complex with fatty acid chloride and pyridine at low temperature. The preparation of the disteraroyl, dipalmitoyl, dimyristoly, and dioleoyl phosphonolecithins by this procedure is described.
摘要
报道了一种从sn-甘油-3-(2-三甲基铵乙基)-膦酸酯的氯化镉配合物合成饱和与不饱和膦酰卵磷脂的方法。通过在低温下用脂肪酸氯化物和吡啶酰化sn-甘油-3(2-三甲基铵乙基)-膦酸酯-氯化镉配合物来获得膦酰卵磷脂。描述了通过该方法制备二硬脂酰、二棕榈酰、二肉豆蔻酰和二油酰膦酰卵磷脂的过程。
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