Merrill P T, Buckley E G, Halperin E C
Department of Ophthalmology, Duke University Medical Center, Durham, NC, USA.
Ophthalmic Genet. 1996 Sep;17(3):115-8. doi: 10.3109/13816819609057114.
Patients with germinal retinoblastoma (those with bilateral disease or positive family history) have a mutation which puts them at risk for developing new tumors. It is unclear whether the frequency of new tumor development is effected by the type of treatment employed. It may be hypothesized that external beam radiation "sterilizes' the whole retina, and thus decreases the risk of new and recurrent tumors. We reviewed our experience with 66 eyes in 47 patients over the past ten years. We did not find a significant difference in the incidence of new and recurrent retinoblastoma among eyes treated with external beam radiation versus focal modalities.
患有生殖细胞性视网膜母细胞瘤的患者（双侧患病或有家族病史者）存在一种突变，这使他们有患新肿瘤的风险。目前尚不清楚新肿瘤发生的频率是否受所采用治疗方式的影响。可以推测，外照射放疗可“杀灭”整个视网膜，从而降低新肿瘤和复发性肿瘤的风险。我们回顾了过去十年中47例患者66只眼的治疗经验。我们发现，接受外照射放疗的眼睛与接受局部治疗的眼睛相比，新发生和复发性视网膜母细胞瘤的发生率没有显著差异。
