Kingston J E, Hungerford J L, Madreperla S A, Plowman P N
Department of Paediatric Oncology, St. Bartholomew's Hospital, London, England.
Arch Ophthalmol. 1996 Nov;114(11):1339-43. doi: 10.1001/archopht.1996.01100140539004.
To determine the visual anatomical results and survival after combined chemotherapy and whole eye radiotherapy for patients with bilateral Reese-Ellsworth group V retinoblastoma.
A national referral center for retinoblastoma.
Fourteen patients with bilateral Reese-Ellsworth group V retinoblastoma seen between March 1, 1989, and April 30, 1995, were treated.
Patients were treated with chemotherapy (using carboplatin, etoposide, and vincristine) and whole eye radiotherapy (40-44 Gy in 20-22 equivalent fractions). A medical record review was performed to determine outcomes.
Survival, eye preservation rate, and visual acuity.
Two patients died, 1 from a primitive neuroectodermal tumor and the other from the meningeal spread of retinoblastoma. Four eyes were enucleated primarily because of severe disease at presentation. Of the remaining 20 eyes, 6 required enucleation. The disease recurred in 4 of those patients, and neovascular glaucoma developed in 2 patients. Of the 12 surviving children, 5 have a visual acuity better than l/60 in at least 1 eye.
Although most of the treated group V eyes could be salvaged with chemotherapy plus radiotherapy, the resultant visual acuity was often poor.
确定双侧里斯-埃尔斯沃思Ⅴ级视网膜母细胞瘤患者在联合化疗和全眼球放疗后的眼部解剖学结果及生存率。
一家全国性视网膜母细胞瘤转诊中心。
对1989年3月1日至1995年4月30日期间诊治的14例双侧里斯-埃尔斯沃思Ⅴ级视网膜母细胞瘤患者进行了治疗。
患者接受化疗（使用卡铂、依托泊苷和长春新碱）和全眼球放疗（40 - 44 Gy，分20 - 22次等效分次）。通过查阅病历确定治疗结果。
生存率、眼球保留率和视力。
2例患者死亡，1例死于原始神经外胚层肿瘤，另1例死于视网膜母细胞瘤的脑膜播散。4只眼因初诊时病情严重而主要行眼球摘除术。其余20只眼中，6只需要摘除。其中4例患者疾病复发，2例患者发生新生血管性青光眼。在12名存活儿童中，5名儿童至少有1只眼的视力优于1/60。
虽然大多数接受治疗的Ⅴ级眼通过化疗加放疗可以挽救，但最终视力往往较差。
