Nork T M, Millecchia L L, de Venecia G B, Myers F L, Vogel K A
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison, USA.
Arch Ophthalmol. 1996 Nov;114(11):1402-6. doi: 10.1001/archopht.1996.01100140602013.
To describe the clinical course and immunocytochemical characteristics of an unusual intraocular tumor.
Immunocytochemical analysis of the enucleated eye with an intraocular mass that markedly waxed and waned in size during 1 year of close observation of a 29-year-old woman.
Most of the tumor was composed of either dying or rapidly proliferating cells. One area located near the retina consisted mostly of well-differentiated cells in uniform sheets (bacillettes) with lacelike glial processes between the tumor cells. Almost all of the differentiated tumor cells were positive for S antigen. In particular, the dominant cell type stained positively for both antibodies known to be specific for those isoforms of S antigen found only in blue cones and rods but not in red or green cones. Only a few of these cells labeled positively with an anti-rhodopsin antibody.
This is the first case of adult retinoblastoma to be confirmed immunocytochemically. The tumor was unusual because the differentiated regions contained bacillettes composed mostly of blue cones. It is possible that this and other adult retinoblastomas may arise from previously existing retinocytomas.
描述一种罕见眼内肿瘤的临床病程及免疫细胞化学特征。
对一名29岁女性的眼球进行免疫细胞化学分析，该眼球内有一肿物，在1年的密切观察期间其大小显著波动。
肿瘤大部分由濒死或快速增殖的细胞组成。靠近视网膜的一个区域主要由排列整齐的高分化细胞（杆菌状细胞）构成，肿瘤细胞之间有花边状神经胶质突起。几乎所有分化的肿瘤细胞S抗原呈阳性。特别地，主要细胞类型对仅在蓝视锥细胞和视杆细胞中发现、而在红视锥细胞或绿视锥细胞中未发现的S抗原亚型的两种特异性抗体均呈阳性染色。这些细胞中只有少数用抗视紫红质抗体呈阳性标记。
这是首例经免疫细胞化学证实的成人视网膜母细胞瘤。该肿瘤不同寻常之处在于其分化区域含有主要由蓝视锥细胞构成的杆菌状细胞。这种及其他成人视网膜母细胞瘤有可能起源于先前存在的视网膜细胞瘤。
