慢性嗜酸性粒细胞性肺炎中嗜酸性粒细胞的异质性

Heterogeneity of eosinophils in chronic eosinophilic pneumonia.

作者信息

Saita N, Yamanaka T, Sugimoto M, Kohrogi H, Suga M, Ando M, Hirashima M

机构信息

Department of Internal Medicine, Kumamoto University, Medical School, Japan.

出版信息

Int Arch Allergy Immunol. 1996;111 Suppl 1:29-31. doi: 10.1159/000237411.

DOI:10.1159/000237411

PMID:8906109

Abstract

It has previously been shown that patients with chronic eosinophilic pneumonia can be divided into 2 groups according to the chemotactic response of their eosinophils to 5 different eosinophil chemotactic factors (ECFs) and laboratory findings. In contrast, eosinophils obtained by bronchoalveolar lavage from both groups responded to all 5 ECFs. The correlation between the two groups and the expression of several antigens (VLA-4, CD69, ICAM-1 and CD11b) on eosinophils. The VLA-4 expression of group 1 eosinophils was higher than that of group 2 eosinophils. More interestingly, eosinophils that migrated towards ECF-PI9 expressed less CD69 than those that migrated towards other STO-2-derived ECF. The heterogeneous response of eosinophils to STO-2-derived ECFs suggests that the population of eosinophils is heterogeneous.

摘要

先前的研究表明，根据嗜酸性粒细胞对5种不同嗜酸性粒细胞趋化因子（ECF）的趋化反应和实验室检查结果，慢性嗜酸性粒细胞性肺炎患者可分为2组。相比之下，两组通过支气管肺泡灌洗获得的嗜酸性粒细胞对所有5种ECF均有反应。两组之间的相关性以及嗜酸性粒细胞上几种抗原（VLA-4、CD69、ICAM-1和CD11b）的表达情况。第1组嗜酸性粒细胞的VLA-4表达高于第2组嗜酸性粒细胞。更有趣的是，向ECF-PI9迁移的嗜酸性粒细胞比向其他STO-2衍生的ECF迁移的嗜酸性粒细胞表达的CD69更少。嗜酸性粒细胞对STO-2衍生的ECF的异质性反应表明嗜酸性粒细胞群体是异质性的。