Yoshida M, Ogata N, Samejima Y, Masuyama K, Ishikawa T, Yoshida N, Hirashima M
Department of Otolaryngology, Kumamoto University Medical School, Japan.
Int Arch Allergy Immunol. 1994;104 Suppl 1(1):15-7. doi: 10.1159/000236739.
Chemotactic responses of eosinophils from patients with allergic rhinitis to 5 STO-2-derived eosinophil chemotactic factors (ECF), IL-3, IL-5 and GM-CSF were examined. The patients were divided into two groups: patients with perennial allergic rhinitis sensitive to Dermatophagoides farinae and those with seasonal allergic rhinitis sensitive to Japanese cedar pollen. There was no essential difference between chemotactic response of eosinophils from the former to STO-2-derived ECF and that from healthy individuals. However, eosinophils from patients with seasonal allergic rhinitis failed to respond to one of the STO-2-derived ECFs, ECF-P19. Before and after nasal antigen provocation, no change occurred in the chemotactic profiles. Furthermore, we found that eosinophils from both types of patients with allergic rhinitis responded not only to IL-3 and GM-CSF but also to IL-5 unlike those of healthy individuals.
对过敏性鼻炎患者的嗜酸性粒细胞对5种STO - 2衍生的嗜酸性粒细胞趋化因子（ECF）、白细胞介素 - 3（IL - 3）、白细胞介素 - 5（IL - 5）和粒细胞 - 巨噬细胞集落刺激因子（GM - CSF）的趋化反应进行了检测。患者被分为两组：对粉尘螨过敏的常年性过敏性鼻炎患者和对日本雪松花粉过敏的季节性过敏性鼻炎患者。前一组患者的嗜酸性粒细胞对STO - 2衍生的ECF的趋化反应与健康个体相比没有本质差异。然而，季节性过敏性鼻炎患者的嗜酸性粒细胞对其中一种STO - 2衍生的ECF，即ECF - P19没有反应。鼻腔抗原激发前后，趋化特征没有变化。此外，我们发现，与健康个体不同，两种类型的过敏性鼻炎患者的嗜酸性粒细胞不仅对IL - 3和GM - CSF有反应，而且对IL - 5也有反应。
