Norvell S T, McCleave J J, Bodurtha A J, Irwin A C
Can J Surg. 1977 Sep;20(5):429-35.
The value of prophylactic node dissection was studied in 147 patients with nonsuperficial malignant melanoma of cutaneous origin; all had clinical stage I disease. Seventy-three patients had prophylactic node dissection and 74 did not. Survival rates were calculated by the actuarial method and were age and sex adjusted. Five-year crude survival rates for these two groups were 62 and 29%, respectively, and the adjusted rates were 70 and 33%, respectively. These significant differences (P less than 0.001) were maintained at 10 years. The difference in survival in the two groups cannot be explained on the basis of age, sex, year of operation, size or location of the primary tumour, or previous incisional biopsy. It is concluded that prophylactic node dissection contributed appreciably to increased survival in this study.
对147例皮肤源性非浅表性恶性黑色素瘤患者进行了预防性淋巴结清扫术的价值研究；所有患者均处于临床I期。73例患者接受了预防性淋巴结清扫术，74例未接受。采用精算方法计算生存率，并对年龄和性别进行了调整。这两组的五年粗生存率分别为62%和29%，调整后的生存率分别为70%和33%。这些显著差异（P<0.001）在10年时仍然存在。两组生存差异不能用年龄、性别、手术年份、原发肿瘤大小或位置，或既往切开活检来解释。得出的结论是，在本研究中预防性淋巴结清扫术对提高生存率有显著贡献。
