Hayaishi O
Osaka Bioscience Institute, Japan.
Adv Exp Med Biol. 1996;398:3-11, vi. doi: 10.1007/978-1-4613-0381-7_1.
In summary, the, PGD2 and E2 are the major endogenous sleep-regulating substances, the former inducing physiological sleep and the latter, wakefulness, in rats, monkeys and probably in humans as well. Second, PGD synthase, the key enzyme in the regulation of sleep, is present mainly in the leptomeninges and choroid plexus, from which it is secreted into the CSF to become beta-trace protein. Third, PGD2 exerts its somnogenic activity at the ventro-rostral surface of the basal forebrain.
总之，在大鼠、猴子以及可能在人类中，前列腺素D2（PGD2）和雌二醇（E2）是主要的内源性睡眠调节物质，前者诱导生理性睡眠，后者诱导觉醒。其次，PGD合成酶是睡眠调节的关键酶，主要存在于软脑膜和脉络丛中，从那里它被分泌到脑脊液中成为β-微量蛋白。第三，PGD2在基底前脑腹侧- Rostral表面发挥其促睡眠活性。
