• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Enantiospecific synthesis and in vitro activity of selective inhibitors of rat brain kynureninase and kynurenine-3-hydroxylase.

作者信息

Giordani A, Corti L, Cini M, Bormetti R, Marconi M, Veneroni O, Speciale C, Varasi M

机构信息

Pharmacia, R&D-CNS, Nerviano Milano, Italy.

出版信息

Adv Exp Med Biol. 1996;398:531-4. doi: 10.1007/978-1-4613-0381-7_83.

DOI:10.1007/978-1-4613-0381-7_83
PMID:8906317
Abstract
摘要

相似文献

1
Enantiospecific synthesis and in vitro activity of selective inhibitors of rat brain kynureninase and kynurenine-3-hydroxylase.大鼠脑犬尿氨酸酶和犬尿氨酸-3-羟化酶选择性抑制剂的对映体特异性合成及体外活性
Adv Exp Med Biol. 1996;398:531-4. doi: 10.1007/978-1-4613-0381-7_83.
2
Benzoylalanine analogues as inhibitors of rat brain kynureninase and kynurenine 3-hydroxylase.苯甲酰丙氨酸类似物作为大鼠脑犬尿氨酸酶和犬尿氨酸3-羟化酶的抑制剂
Adv Exp Med Biol. 1996;398:499-505. doi: 10.1007/978-1-4613-0381-7_77.
3
Kynurenine hydroxylase and kynureninase inhibitors as tools to study the role of kynurenine metabolites in the central nervous system.犬尿氨酸羟化酶和犬尿氨酸酶抑制剂作为研究犬尿氨酸代谢产物在中枢神经系统中作用的工具。
Adv Exp Med Biol. 1996;398:203-10. doi: 10.1007/978-1-4613-0381-7_33.
4
Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase.犬尿氨酸在小鼠血液和大脑中的代谢:犬尿氨酸羟化酶和犬尿氨酸酶选择性抑制剂的作用
J Neurochem. 1996 Aug;67(2):692-8. doi: 10.1046/j.1471-4159.1996.67020692.x.
5
Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.犬尿氨酸羟化酶和犬尿氨酸酶抑制剂可增加犬尿喹啉酸在大脑中的生成,并具有镇静和抗惊厥活性。
Neuroscience. 1994 Jul;61(2):237-43. doi: 10.1016/0306-4522(94)90227-5.
6
Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.为寻找新型神经保护剂而对犬尿氨酸途径进行的调控。犬尿氨酸-3-羟化酶强效抑制剂(间硝基苯甲酰)丙氨酸的合成与初步评价。
J Med Chem. 1994 Mar 4;37(5):647-55. doi: 10.1021/jm00031a015.
7
Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase.犬尿氨酸羟化酶和/或犬尿氨酸酶抑制所产生的神经化学和行为效应的比较。
J Neurochem. 1995 Sep;65(3):1176-83. doi: 10.1046/j.1471-4159.1995.65031176.x.
8
4-Phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase.4-苯基-4-氧代丁酸衍生物,犬尿氨酸3-羟化酶抑制剂。
Bioorg Med Chem Lett. 1998 Oct 20;8(20):2907-12. doi: 10.1016/s0960-894x(98)00517-4.
9
Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase.免疫激活小鼠体内喹啉酸的形成:使用(间硝基苯甲酰基)-丙氨酸(mNBA)和3,4-二甲氧基-[-N-4-(-3-硝基苯基)噻唑-2-基]-苯磺酰胺(Ro 61-8048)的研究,这两种是犬尿氨酸羟化酶的强效选择性抑制剂。
Neuropharmacology. 1999 Aug;38(8):1225-33. doi: 10.1016/s0028-3908(99)00048-9.
10
Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.
J Med Chem. 1997 Dec 19;40(26):4378-85. doi: 10.1021/jm970467t.

引用本文的文献

1
Pharmacophore-Based Virtual Screening of Novel Competitive Inhibitors of the Neurodegenerative Disease Target Kynurenine-3-Monooxygenase.基于药效团的神经退行性疾病靶标犬尿氨酸-3-单加氧酶新型竞争性抑制剂的虚拟筛选。
Molecules. 2021 May 31;26(11):3314. doi: 10.3390/molecules26113314.