大鼠脑犬尿氨酸酶和犬尿氨酸-3-羟化酶选择性抑制剂的对映体特异性合成及体外活性 - Suppr | 超能文献

Enantiospecific synthesis and in vitro activity of selective inhibitors of rat brain kynureninase and kynurenine-3-hydroxylase.

作者信息

Giordani A, Corti L, Cini M, Bormetti R, Marconi M, Veneroni O, Speciale C, Varasi M

机构信息

Pharmacia, R&D-CNS, Nerviano Milano, Italy.

出版信息

Adv Exp Med Biol. 1996;398:531-4. doi: 10.1007/978-1-4613-0381-7_83.

DOI:10.1007/978-1-4613-0381-7_83

Abstract

摘要

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Enantiospecific synthesis and in vitro activity of selective inhibitors of rat brain kynureninase and kynurenine-3-hydroxylase.大鼠脑犬尿氨酸酶和犬尿氨酸-3-羟化酶选择性抑制剂的对映体特异性合成及体外活性

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Benzoylalanine analogues as inhibitors of rat brain kynureninase and kynurenine 3-hydroxylase.苯甲酰丙氨酸类似物作为大鼠脑犬尿氨酸酶和犬尿氨酸3-羟化酶的抑制剂

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Kynurenine hydroxylase and kynureninase inhibitors as tools to study the role of kynurenine metabolites in the central nervous system.犬尿氨酸羟化酶和犬尿氨酸酶抑制剂作为研究犬尿氨酸代谢产物在中枢神经系统中作用的工具。

Adv Exp Med Biol. 1996;398:203-10. doi: 10.1007/978-1-4613-0381-7_33.

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Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase.犬尿氨酸在小鼠血液和大脑中的代谢：犬尿氨酸羟化酶和犬尿氨酸酶选择性抑制剂的作用

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Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.犬尿氨酸羟化酶和犬尿氨酸酶抑制剂可增加犬尿喹啉酸在大脑中的生成，并具有镇静和抗惊厥活性。

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Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.为寻找新型神经保护剂而对犬尿氨酸途径进行的调控。犬尿氨酸-3-羟化酶强效抑制剂（间硝基苯甲酰）丙氨酸的合成与初步评价。

J Med Chem. 1994 Mar 4;37(5):647-55. doi: 10.1021/jm00031a015.

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Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase.犬尿氨酸羟化酶和/或犬尿氨酸酶抑制所产生的神经化学和行为效应的比较。

J Neurochem. 1995 Sep;65(3):1176-83. doi: 10.1046/j.1471-4159.1995.65031176.x.

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4-Phenyl-4-oxo-butanoic acid derivatives inhibitors of kynurenine 3-hydroxylase.4-苯基-4-氧代丁酸衍生物，犬尿氨酸3-羟化酶抑制剂。

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Quinolinic acid formation in immune-activated mice: studies with (m-nitrobenzoyl)-alanine (mNBA) and 3,4-dimethoxy-[-N-4-(-3-nitrophenyl)thiazol-2yl]-benzenesul fonamide (Ro 61-8048), two potent and selective inhibitors of kynurenine hydroxylase.免疫激活小鼠体内喹啉酸的形成：使用（间硝基苯甲酰基）-丙氨酸（mNBA）和3,4-二甲氧基-[-N-4-（-3-硝基苯基）噻唑-2-基]-苯磺酰胺（Ro 61-8048）的研究，这两种是犬尿氨酸羟化酶的强效选择性抑制剂。

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Synthesis and biochemical evaluation of N-(4-phenylthiazol-2-yl)benzenesulfonamides as high-affinity inhibitors of kynurenine 3-hydroxylase.

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