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Kynurenine hydroxylase and kynureninase inhibitors as tools to study the role of kynurenine metabolites in the central nervous system.

作者信息

Moroni F, Carpenedo R, Chiarugi A

机构信息

Department of Preclinical and Clinical Pharmacology, University of Florence, Firenze, Italy.

出版信息

Adv Exp Med Biol. 1996;398:203-10. doi: 10.1007/978-1-4613-0381-7_33.

DOI:10.1007/978-1-4613-0381-7_33
PMID:8906267
Abstract
摘要

相似文献

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Kynurenine hydroxylase and kynureninase inhibitors as tools to study the role of kynurenine metabolites in the central nervous system.犬尿氨酸羟化酶和犬尿氨酸酶抑制剂作为研究犬尿氨酸代谢产物在中枢神经系统中作用的工具。
Adv Exp Med Biol. 1996;398:203-10. doi: 10.1007/978-1-4613-0381-7_33.
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Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase.犬尿氨酸在小鼠血液和大脑中的代谢：犬尿氨酸羟化酶和犬尿氨酸酶选择性抑制剂的作用
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Kynurenine-3-hydroxylase and its selective inhibitors. Molecular modeling studies.犬尿氨酸-3-羟化酶及其选择性抑制剂。分子模拟研究。
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Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenate and have sedative and anticonvulsant activities.犬尿氨酸羟化酶和犬尿氨酸酶抑制剂可增加犬尿喹啉酸在大脑中的生成，并具有镇静和抗惊厥活性。
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Modulation of the kynurenine pathway in search for new neuroprotective agents. Synthesis and preliminary evaluation of (m-nitrobenzoyl)alanine, a potent inhibitor of kynurenine-3-hydroxylase.为寻找新型神经保护剂而对犬尿氨酸途径进行的调控。犬尿氨酸-3-羟化酶强效抑制剂（间硝基苯甲酰）丙氨酸的合成与初步评价。
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28833, a selective kynurenine 3-hydroxylase inhibitor. Effects on the kynurenine pathway metabolites in the gerbil.28833，一种选择性犬尿氨酸3-羟化酶抑制剂。对沙鼠体内犬尿氨酸途径代谢产物的影响。
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Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase.犬尿氨酸羟化酶和/或犬尿氨酸酶抑制所产生的神经化学和行为效应的比较。
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Differential effects of bromination on substrates and inhibitors of kynureninase from Pseudomonas fluorescens.
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