Petrovich G D, Risold P Y, Swanson L W
Department of Biological Sciences, University of Southern California, Los Angeles 90089-2520, USA.
J Comp Neurol. 1996 Oct 21;374(3):387-420. doi: 10.1002/(SICI)1096-9861(19961021)374:3<387::AID-CNE6>3.0.CO;2-Y.
The organization of axonal projections from the basomedial nucleus of the amygdala (BMA) was examined with the Phaseolus vulgaris leucoagglutinin (PHAL) method in adult male rats. The anterior and posterior parts of the BMA, recognized on cytoarchitectonic grounds, display very different projection patterns. Within the amygdala, the anterior basomedial nucleus (BMAa) heavily innervates the central, medial, and anterior cortical nuclei. In contrast, the posterior basomedial nucleus (BMAp) sends a dense projection to the lateral nucleus, and to restricted parts of the central and medial nuclei. Extra-amygdalar projections from the BMA are divided into ascending and descending components. The former end in the cerebral cortex, striatum, and septum. The BMAa mainly innervates olfactory (piriform, transitional) and insular areas, whereas the BMAp also innervates inferior temporal (perirhinal, ectorhinal) and medial prefrontal (infralimbic, prelimbic) areas and the hippocampal formation. Within the striatum, the BMAa densely innervates the striatal fundus, whereas the nucleus accumbens receives a heavy input from the BMAp. Both parts of the BMA send massive projections to distinct regions of the bed nuclei of the stria terminalis. Descending projections from the BMA end primarily in the hypothalamus. The BMAa sends a major input to the lateral hypothalamic area, whereas the BMAp innervates the ventromedial nucleus particularly heavily. Injections were also placed in the anterior cortical nucleus (COAa), a cell group superficially adjacent to the BMAa. PHAL-labeled axons from this cell group mainly ascend into the amygdala and olfactory areas, and descend into the thalamus and lateral hypothalamic area. Based on connections, the COAa and BMAa are part of the same functional system. The results suggest that cytoarchitectonically distinct anterior and posterior parts of the BMA are also hodologically distinct and form parts of distinct anatomical circuits probably involved in mediating different behaviors (for example, feeding and social behaviors vs. emotion-related learning, respectively).
采用菜豆白细胞凝集素（PHAL）法，在成年雄性大鼠中研究了杏仁核基底内侧核（BMA）轴突投射的组织情况。基于细胞构筑学特征识别出的BMA前部和后部，呈现出非常不同的投射模式。在杏仁核内，前基底内侧核（BMAa）大量支配中央核、内侧核和前皮质核。相比之下，后基底内侧核（BMAp）向外侧核以及中央核和内侧核的特定部分发出密集投射。BMA的杏仁核外投射分为升支和降支。前者终止于大脑皮质、纹状体和隔区。BMAa主要支配嗅觉（梨状、过渡性）和岛叶区域，而BMAp还支配颞下（嗅周、嗅外）和内侧前额叶（缘下、前边缘）区域以及海马结构。在纹状体内，BMAa密集支配纹状体底部，而伏隔核接受来自BMAp的大量输入。BMA的两个部分都向终纹床核的不同区域发出大量投射。BMA的降支主要终止于下丘脑。BMAa向外侧下丘脑区发出主要输入，而BMAp特别密集地支配腹内侧核。注射也被置于前皮质核（COAa），这是一个与BMAa表面相邻的细胞群。来自该细胞群的PHAL标记轴突主要向上进入杏仁核和嗅觉区域，并向下进入丘脑和外侧下丘脑区。基于连接情况，COAa和BMAa是同一功能系统的一部分。结果表明，在细胞构筑学上不同的BMA前部和后部在神经传导通路学上也不同，并且形成了可能分别参与介导不同行为（例如，进食和社交行为与情绪相关学习）的不同解剖回路的一部分。
