Division of Cognitive Neuroscience, Department of Biomedicine, University of Basel, Basel, Switzerland.
Research Cluster Molecular and Cognitive Neurosciences, University of Basel, Basel, Switzerland.
Nat Commun. 2023 Sep 14;14(1):5694. doi: 10.1038/s41467-023-41380-w.
Episodic memory, the ability to consciously recollect information and its context, varies substantially among individuals. While prior fMRI studies have identified certain brain regions linked to successful memory encoding at a group level, their role in explaining individual memory differences remains largely unexplored. Here, we analyze fMRI data of 1,498 adults participating in a picture encoding task in a single MRI scanner. We find that individual differences in responsivity of the hippocampus, orbitofrontal cortex, and posterior cingulate cortex account for individual variability in episodic memory performance. While these regions also emerge in our group-level analysis, other regions, predominantly within the lateral occipital cortex, are related to successful memory encoding but not to individual memory variation. Furthermore, our network-based approach reveals a link between the responsivity of nine functional connectivity networks and individual memory variability. Our work provides insights into the neurofunctional correlates of individual differences in visual episodic memory performance.
情景记忆，即有意识地回忆信息及其背景的能力，在个体之间存在很大差异。虽然之前的 fMRI 研究已经确定了某些与群体水平的成功记忆编码相关的大脑区域，但它们在解释个体记忆差异方面的作用在很大程度上仍未得到探索。在这里，我们分析了 1498 名成年人在单个 MRI 扫描仪中进行图片编码任务的 fMRI 数据。我们发现，海马体、眶额皮质和后扣带回皮质的反应性个体差异解释了情景记忆表现的个体差异。虽然这些区域也出现在我们的组水平分析中，但其他区域，主要是外侧枕叶皮质，与成功的记忆编码有关，但与个体记忆变化无关。此外，我们的基于网络的方法揭示了九个功能连接网络的反应性与个体记忆变异性之间的联系。我们的工作为视觉情景记忆表现个体差异的神经功能相关性提供了新的见解。
