PAF and PAF acetylhydrolase in the nervous system.
作者信息
Hattori M, Aoki J, Arai H, Inoue K
机构信息
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
出版信息
J Lipid Mediat Cell Signal. 1996 Sep;14(1-3):99-102. doi: 10.1016/0929-7855(96)00514-7.
PMID:8906551
Abstract
PAF acetylhydrolase is a key enzyme of PAF inactivation. Intracellular PAF acetylhydrolase isoform Ib is a heterotrimeric enzyme composed of alpha-, beta- and gamma-subunits. The beta- and gamma-subunits act as a catalytic unit and their amino acid sequences are homologous. The alpha-subunit is not essential for catalytic activity but is a product of the causative gene for Miller-Dicker lissencephaly, suggesting this subunit plays an important role in brain development.
摘要
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