Mass-Schwartz A, Weinstock R S, Wagner R L, Abelmann W H
Cardiovasc Res. 1977 Jul;11(4):367-74. doi: 10.1093/cvr/11.4.367.
Ventricular pressure-volume curves were examined in 10 pre-oedematous cardiomyopathic Syrian hamsters, aged 120 d, and 10 oedematous cardiomyopathic hamsters, aged 210 d, and compared with 10 and 8 age-matched controls, respectively. Previous studies had shown filling pressures and cardiac output to be normal in the pre-oedematous stage. In contrast, the oedematous stage was characterised by elevated filling pressures and increased cardiac output, raising the question whether this stage represents true myocardial failure or circulatory congestion associated with decreased ventricular compliance. Compliance, defined as dV/dP, was derived simulataneously for both ventricles from post-mortem pressure-volume curves from 0 to 2.66 kPa (0 to 20 mmHg). Left ventricular tissue elastic modulus, E, defined as dsigma/depsilon or the incremental stress (sigma) for an increment of strain (epsilon), was derived from the compliance curves and certain linear dimensions of the heart. At isobaric intervals, compliance did not differ between control and myopathic ventricles. At pressures corresponding to previously measured, naturally prevailing end-diastolic pressures, the myopathic ventricles were significantly dilated in both stages; end-diastolic compliance was normal in pre-oedematous hamsters, but was significantly decreased in the oedematous animals. Left ventricular elastic modulus was elevated at all values of sigma in both groups of myopathic animals.
对10只120日龄的水肿前期心肌病叙利亚仓鼠和10只210日龄的水肿性心肌病仓鼠进行了心室压力-容积曲线检查，并分别与10只和8只年龄匹配的对照仓鼠进行比较。先前的研究表明，在水肿前期阶段，充盈压和心输出量是正常的。相比之下，水肿阶段的特征是充盈压升高和心输出量增加，这就引发了一个问题，即这个阶段是代表真正的心肌衰竭还是与心室顺应性降低相关的循环充血。顺应性定义为dV/dP，是从死后0至2.66 kPa（0至20 mmHg）的压力-容积曲线同时推导得出的两个心室的数值。左心室组织弹性模量E定义为dsigma/depsilon或应变（epsilon）增量时的增量应力（sigma），它是从顺应性曲线和心脏的某些线性尺寸推导得出的。在等压间隔时，对照心室和病变心室的顺应性没有差异。在对应于先前测量的自然存在的舒张末期压力的压力下，病变心室在两个阶段均显著扩张；水肿前期仓鼠的舒张末期顺应性正常，但水肿动物的舒张末期顺应性显著降低。两组病变动物在所有sigma值下左心室弹性模量均升高。
