Rolland J P, Santaella C, Vierling P
Laboratoire de Chimie Moleculaire, Universite de Nice Sophia-Antipolis, Faculte des Sciences, France.
Chem Phys Lipids. 1996 Jan 25;79(1):71-7. doi: 10.1016/0009-3084(95)02515-4.
Surface pressure-area isotherms of a series of fluorinated DFnCmPC phosphatidylcholines bearing two acyl chains ended by a perfluoroalkyl Fn tail of variable lengths were recorded at the air-water interface. The limiting molecular areas (Ax), the collapse pressures (pi c), the pressures of the liquid-expanded to liquid-condensed phase transition (pi t) and their associated Ac and At areas were deduced from these experiments and compared to those of their hydrocarbon DMPC, DPPC and DSPC analogs. The impact of the fluorinated tails on the characteristics of phosphatidylcholine monolayers, as well as the dependence of the observed effects on the length of these tails and their relative weight with respect to the whole hydrophobic chain length, i.e. the degree of 'fluorination' of the monolayer, is interpreted in terms of steric hindrance, hydrophobicity and chain-chain interaction balance.
在空气-水界面记录了一系列带有两条由不同长度的全氟烷基Fn尾端封端的酰基链的氟化DFnCmPC磷脂酰胆碱的表面压力-面积等温线。从这些实验中推导出极限分子面积（Ax）、塌陷压力（πc）、液体膨胀到液体凝聚相转变的压力（πt）以及它们相关的Ac和At面积，并与它们的烃类DMPC、DPPC和DSPC类似物进行比较。根据空间位阻、疏水性和链-链相互作用平衡来解释氟化尾对磷脂酰胆碱单层特性的影响，以及观察到的效应与这些尾的长度及其相对于整个疏水链长度的相对权重（即单层的“氟化”程度）的依赖性。
