Economopoulos T, Asprou N, Stathakis N, Papageorgiou E, Dervenoulas J, Xanthaki K, Raptis S
Second Department of Internal Medicine--Propaedeutic, Athens University, "Evangelismos" Hospital, Greece.
Leuk Lymphoma. 1996 Mar;21(1-2):131-6. doi: 10.3109/10428199609067590.
Among 318 cases of non-Hodgkin's lymphoma (NHL) treated in our unit, 145 (45.6%) had primary extranodal NHL (PE-NHL). The stomach was the most common site (42.1%), followed by the PE-NHL of the head and neck region. Histologically aggressive histologies (65.5% intermediate and 20.7% high grade) predominated. 89.6% of the cases were localized (stage IE, 51% and stage II, 38.6%) but 28% had B symptoms. CR was achieved in 82.1% of the cases. 5-years disease free survival and overall survival were both 65%. Factors that influence prognosis were stage and high grade histology. Among various primary sites the Waldeyer's ring, small intestine and testes had the worse prognosis. Compared to nodal NHL, the PE-NHL were more frequently localized, belonged more often to aggressive histologies and had more often distal extranodal relapses. CR rates and disease free and overall survival were significantly better for PE-NHL. The survival rates, however, listed according to stage and histology for nodal and PE-NHL were not different. We conclude that although PE-NHL differed from nodal NHL in several respects, prognosis is mainly a factor of stage and histology rather than of the primary localization per se.
在我们科室治疗的318例非霍奇金淋巴瘤（NHL）患者中，145例（45.6%）为原发性结外NHL（PE-NHL）。胃部是最常见的部位（42.1%），其次是头颈部的PE-NHL。组织学上侵袭性组织学类型（65.5%为中级和20.7%为高级别）占主导。89.6%的病例为局限性病变（IE期占51%，II期占38.6%），但28%有B症状。82.1%的病例达到完全缓解（CR）。5年无病生存率和总生存率均为65%。影响预后的因素是分期和高级别组织学类型。在各个原发部位中，Waldeyer环、小肠和睾丸的预后较差。与结内NHL相比，PE-NHL更常为局限性病变，更常属于侵袭性组织学类型，且更常发生远处结外复发。PE-NHL的CR率、无病生存率和总生存率明显更好。然而，根据分期和组织学列出的结内和PE-NHL的生存率并无差异。我们得出结论，尽管PE-NHL在几个方面与结内NHL不同，但预后主要是分期和组织学的因素，而非原发部位本身。
