Simonsen P E, Meyrowitsch D W, Makunde W H, Magnussen P
Danish Bilharziasis Laboratory, Denmark.
Acta Trop. 1995 Dec;60(3):179-87. doi: 10.1016/0001-706x(95)00126-y.
Individuals from three villages in northeastern Tanzania, located 40 km inland from the Indian Ocean coast, were surveyed for parasitological and clinical evidence of bancroftian filariasis. Microfilarial (mf) prevalences ranged from 22.2 to 37.6%, and mf geometric mean intensities (GMI) ranged from 546 to 735 mf/ml blood, in the three villages. Microfilaraemia was rare in children below five years. The mf prevalences increased with age, reaching from 35.9 to 49.2% in individuals aged 45 years and above. No association between mf GMI and age was observed in any of the villages. Hydrocele was the most common chronic clinical manifestation, with prevalences ranging from 14.5 to 21.3% for all males, and from 52.9 to 62.1% for males aged 45 years and above. From 0.6 to 3.3% of the inhabitants in the three villages had elephantiasis, which most often affected the legs. Microfilaraemia was common in males with hydrocele, and in males of 45 years and above there was no significant difference in mf prevalence between males with (42.5%) and without (55.2%) hydrocele. In contrast, microfilariae were only detected in the blood from one of 18 individuals with elephantiasis. With respect to hydrocele, the present results do not support recently forwarded hypotheses assuming a general negative relationship between microfilaraemia and chronic clinical manifestations in bancroftian filariasis.
对来自坦桑尼亚东北部三个村庄的居民进行了调查，这些村庄位于距印度洋海岸内陆40公里处，以寻找班氏丝虫病的寄生虫学和临床证据。在这三个村庄中，微丝蚴（mf）感染率在22.2%至37.6%之间，mf几何平均强度（GMI）在每毫升血液546至735条mf之间。五岁以下儿童微丝蚴血症罕见。mf感染率随年龄增长而升高，45岁及以上人群中mf感染率从35.9%升至49.2%。在任何一个村庄中，均未观察到mf GMI与年龄之间存在关联。鞘膜积液是最常见的慢性临床表现，所有男性的患病率在14.5%至21.3%之间，45岁及以上男性的患病率在52.9%至62.1%之间。三个村庄中有0.6%至3.3%的居民患有象皮肿，象皮肿最常累及腿部。微丝蚴血症在患有鞘膜积液的男性中很常见，在45岁及以上男性中，患有鞘膜积液的男性（42.5%）和未患鞘膜积液的男性（55.2%）之间的mf感染率无显著差异。相比之下，在18例象皮肿患者中，仅1例血液中检测到微丝蚴。关于鞘膜积液，目前的结果不支持最近提出的假设，即认为班氏丝虫病中微丝蚴血症与慢性临床表现之间普遍存在负相关关系。
