恶性蝾螈瘤和恶性周围神经鞘瘤的细胞遗传学分析及文献综述
Cytogenetic analysis of a malignant triton tumor and a malignant peripheral nerve sheath tumor and a review of the literature.
作者信息
McComb E N, McComb R D, DeBoer J M, Neff J R, Bridge J A
机构信息
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5440, USA.
出版信息
Cancer Genet Cytogenet. 1996 Oct 1;91(1):8-12. doi: 10.1016/s0165-4608(96)00125-2.
Cytogenetic analyses of malignant peripheral nerve sheath tumors (MPNST) and malignant triton tumors (MTT) are few to date. Two separate triton tumor specimens from one patient and a MPNST specimen from another patient, both with peripheral neurofibromatosis (NF-1, von Recklinghausen disease), showed complex near-triploid complements and partial deletion of the short arm of chromosome 1. Notably, a structural abnormality of chromosome 17 was detected in the MPNST, and loss of chromosome 22 was detected in the MTT. The genes for peripheral neurofibromatosis (NF-1) and central neurofibromatosis (NF-2) have been mapped to these two chromosomes respectively.
迄今为止，对恶性外周神经鞘瘤（MPNST）和恶性蝾螈瘤（MTT）的细胞遗传学分析较少。来自一名患者的两个独立的蝾螈瘤标本以及来自另一名患者的一个MPNST标本，二者均患有外周神经纤维瘤病（NF-1，冯雷克林霍增氏病），显示出复杂的近三倍体核型以及1号染色体短臂的部分缺失。值得注意的是，在MPNST中检测到17号染色体的结构异常，在MTT中检测到22号染色体的缺失。外周神经纤维瘤病（NF-1）和中枢神经纤维瘤病（NF-2）的基因分别定位于这两条染色体上。
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