儿童中枢神经系统肿瘤的细胞遗传学

Cytogenetics of pediatric central nervous system tumors.

作者信息

Sainati L, Bolcato S, Montaldi A, Celli P, Stella M, Leszl A, Silvestro L, Perilongo G, Cordero di Montezemolo L, Basso G

机构信息

Dipartimento di Pediatria, Università di Padova, Italy.

出版信息

Cancer Genet Cytogenet. 1996 Oct 1;91(1):13-27. doi: 10.1016/s0165-4608(96)00036-2.

DOI:10.1016/s0165-4608(96)00036-2

PMID:8908162

Abstract

A cytogenetic analysis was performed on short-term cultures of 43 previously untreated childhood central nervous system neoplasms of various histology. The cells were obtained from pediatric patients, none of whom had received therapy before karyotypic evaluation. Successful chromosome studies were performed on 24 tumors. The most commonly detected structural abnormalities involved chromosomes 1 and 17. Other structural chromosome abnormalities involved chromosomes 3, 6, 8, 9, 11, 12, and 20.

摘要

对43例未经治疗的不同组织学类型的儿童中枢神经系统肿瘤进行了短期培养的细胞遗传学分析。细胞取自儿科患者，在进行核型评估之前，这些患者均未接受过治疗。对24个肿瘤进行了成功的染色体研究。最常检测到的结构异常涉及1号和17号染色体。其他结构染色体异常涉及3号、6号、8号、9号、11号、12号和20号染色体。