亚细胞分布，五氯苯酚风险评估中的一个因素。

Subcellular distribution, a factor in risk evaluation of pentachlorophenol.

作者信息

Arrhenius E, Renberg L, Johansson L

出版信息

Chem Biol Interact. 1977 Jul;18(1):23-34. doi: 10.1016/0009-2797(77)90138-7.

Abstract

Pentachlorophenol (PCP) is a potent uncoupler of mitochondrial phosphorylation in vitro and also interferes with microsomal detoxication functions in vitro. This favours flavin mediated oxygenation compared with flavin cytochrome P-450 dependent reactions. Gas chromatographic analysis of subcellular fractions, obtained by zonal centrifugation showed markedly lower PCP concentration in mitochondria and a high accumulation in microsomes compared with cytosol. This increases the likelihood that PCP in vivo causes a malfunction in microsomal detoxication.

摘要

五氯苯酚（PCP）在体外是一种有效的线粒体磷酸化解偶联剂，并且在体外也会干扰微粒体解毒功能。与黄素细胞色素P-450依赖性反应相比，这有利于黄素介导的氧化作用。通过区带离心获得的亚细胞组分的气相色谱分析表明，与胞质溶胶相比，线粒体中的PCP浓度明显较低，而微粒体中PCP大量蓄积。这增加了PCP在体内导致微粒体解毒功能异常的可能性。