Mohan V, Premalatha G, Padma A, Chari S T, Pitchumoni C S
M.V. Diabetes Specialties Center, Madras, India.
Diabetes Care. 1996 Nov;19(11):1274-8. doi: 10.2337/diacare.19.11.1274.
To determine the long-term survival and causes of death in fibrocalculous pancreatic diabetes, a form of diabetes secondary to tropical chronic pancreatitis.
A cohort of 370 patients with fibrocalculous pancreatic diabetes were analyzed with respect to survival time from the date of occurrence of the first symptom of the disease as well as after the onset of diabetes. The cause of death was analyzed in the patients who died. Cumulative survival rates were calculated by the actuarial method, and life table graphs were plotted by mathematical calculations.
Long-term survival of patients with fibrocalculous pancreatic diabetes is much better today than that described 30 years ago. About 80% of patients were alive 35 years after the first episode of abdominal pain. The median survival time after the diagnosis of diabetes was 25 years. These figures, however, are still considerably lower than the life expectancy of the age- and sex-matched general population. Diabetic nephropathy was the main cause of death. Pancreatic cancer and other chronic pancreatitis-related causes as well as malnutrition and infections were also important contributors to mortality.
The overall prognosis for patients with fibrocalculous pancreatic diabetes appears to have improved possibly because of earlier diagnosis, better management of diabetes, and improved nutrition.
确定纤维钙化性胰腺糖尿病（一种继发于热带慢性胰腺炎的糖尿病）的长期生存率及死亡原因。
对370例纤维钙化性胰腺糖尿病患者进行分析，记录从疾病首发症状出现之日起以及糖尿病发病后的生存时间。对死亡患者的死因进行分析。采用精算方法计算累积生存率，并通过数学计算绘制生命表图。
如今，纤维钙化性胰腺糖尿病患者的长期生存率比30年前描述的情况要好得多。约80%的患者在首次出现腹痛35年后仍存活。糖尿病诊断后的中位生存时间为25年。然而，这些数字仍远低于年龄和性别匹配的普通人群的预期寿命。糖尿病肾病是主要死因。胰腺癌和其他与慢性胰腺炎相关的病因以及营养不良和感染也是导致死亡的重要因素。
纤维钙化性胰腺糖尿病患者的总体预后似乎有所改善，这可能是由于早期诊断、更好的糖尿病管理以及营养状况的改善。
