哈萨克斯坦的爱泼斯坦-巴尔病毒相关胃癌
Epstein-Barr virus-associated gastric carcinoma in Kazakhstan.
作者信息
Alipov Gabit, Nakayama Toshiyuki, Nakashima Masahiro, Wen Chun-Yang, Niino Daisuke, Kondo Hisayoshi, Pruglo Yuri, Sekine Ichiro
机构信息
Division of Scientific Data Regsitry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
出版信息
World J Gastroenterol. 2005 Jan 7;11(1):27-30. doi: 10.3748/wjg.v11.i1.27.
AIM
To investigate the incidence of Epstein-Barr virus-associated gastric cancer (EBV-GC) in Kazakhstan and to compare it with that in Russia, Western and Asian countries in order to evaluate the significance of epidemiopathologic and ethnic factors.
METHODS
In situ hybridization (ISH) of EBV-encoded small RNA-1 (EBER-1) was used to identify the presence of EBER-1 signal in 139 formalin-fixed and paraffin-embedded GC tissues from Kazakhstan.
RESULTS
EBER-1 expression was observed in the nuclei of 10% of the cases of GC (14/139), but not in the surrounding normal mucosa. The incidence of the diffuse type of EBV-GC was significantly higher in Kazakhstan (14%, 13/91) than that of the intestinal type (2%, 1/48). Furthermore, the incidence was significantly higher in males (14%, 12/89) than in females (3.7%, 2/53) from all countries. The overall incidence of EBV-GC increased from 6.7% in Asian countries to 8.7% in Russia, 10.1% in Kazakhstan and 16% in Western countries.
CONCLUSION
Geographical differences in the incidence of EBV-GC may reflect the epidemiologic factors and/or dietary habits independent of histological type and sex.
目的
调查哈萨克斯坦爱泼斯坦-巴尔病毒相关胃癌（EBV-GC）的发病率，并与俄罗斯、西方国家和亚洲国家进行比较，以评估流行病学病理和种族因素的意义。
方法
采用原位杂交（ISH）检测139例来自哈萨克斯坦的福尔马林固定石蜡包埋胃癌组织中EBV编码小RNA-1（EBER-1）的信号。
结果
10%的胃癌病例（14/139）细胞核中观察到EBER-1表达，但周围正常黏膜中未观察到。哈萨克斯坦弥漫型EBV-GC的发病率（14%，13/91）显著高于肠型（2%，1/48）。此外，所有国家男性的发病率（14%，12/89）显著高于女性（3.7%，2/53）。EBV-GC的总体发病率从亚洲国家的6.7%增至俄罗斯的8.7%、哈萨克斯坦的10.1%和西方国家的16%。
结论
EBV-GC发病率的地理差异可能反映了独立于组织学类型和性别的流行病学因素和/或饮食习惯。
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