Sakamoto J, Nakazato H, Teramukai S, Ohashi Y, Takahashi Y, Mai M, Toge T, Okura H, Kodaira S, Maetani S, Okajima K, Nomoto K, Hattori T, Inokuchi K
Department of Surgery, Aichi Prefectural Hospital, Okazaki, Japan.
Surg Oncol. 1996 Jun;5(3):133-9. doi: 10.1016/s0960-7404(96)80013-2.
A large-scale retrospective study was undertaken to evaluate the association between preoperative plasma carcinoembryonic antigen (CEA) levels and the prognosis of 2768 gastric cancer patients who underwent curative gastrectomy between 1983 and 1984 at 66 leading medical institutions in Japan Postoperative follow-up was at least 5 years. Preoperative plasma CEA levels were also analysed against other prognostic factors. Preoperative plasma CEA levels showed strong correlations to the degree of lymph node metastasis (P < 0.001), TNM stage (P = 0.004) and the histopathology of the gastric cancer (P < 0.001). Preoperative CEA levels were also evaluated against survival, after being adjusted for the effect of clinically important factors by multivariate analysis. Patients with lower preoperative plasma CEA levels survived significantly longer than patients with higher CEA levels (P = 0.0001). This analysis demonstrates that curatively resected gastric cancer patients with higher preoperative plasma CEA levels have a poorer prognosis than those with lower levels, despite the adjustment for the effects of major prognostic factors.
一项大规模回顾性研究旨在评估术前血浆癌胚抗原（CEA）水平与1983年至1984年期间在日本66家主要医疗机构接受根治性胃切除术的2768例胃癌患者预后之间的关联。术后随访至少5年。还针对其他预后因素分析了术前血浆CEA水平。术前血浆CEA水平与淋巴结转移程度（P<0.001）、TNM分期（P = 0.004）和胃癌组织病理学（P<0.001）密切相关。在通过多变量分析对临床重要因素的影响进行校正后，还评估了术前CEA水平与生存率的关系。术前血浆CEA水平较低的患者比CEA水平较高的患者存活时间显著更长（P = 0.0001）。该分析表明，尽管对主要预后因素的影响进行了校正，但术前血浆CEA水平较高的根治性切除胃癌患者的预后比水平较低的患者更差。
