Swartz B E, Simpkins F, Halgren E, Mandelkern M, Brown C, Krisdakumtorn T, Gee M
Veteran's Administration Medical Center, West Los Angeles, Neurology Service, CA, USA.
Neurology. 1996 Nov;47(5):1203-12. doi: 10.1212/wnl.47.5.1203.
It is generally believed that patients with primary generalized epilepsy have normal cognition and neuroimaging studies. We have previously shown that patients with juvenile myoclonic epilepsy (JME) have impaired visual working memory. In this study we examined relative regional changes in 18FDG uptake during a visual working memory paradigm in patients with JME. At rest, there were regional decreases in relative glucose uptake compared to controls. Unlike control subjects, increased activity in the dorsolateral prefrontal cortex was not found during the working memory task. Other regions with increased uptake in controls, such as premotor cortex and basal frontal cortex, also showed no increases, whereas medical temporal structures appeared to play a role in JME but not in control subjects' task performance. The data suggest that JME, a type of primary generalized epilepsy, may suffer from cortical disorganization that affects both the epileptogenic potential and frontal lobe cognitive functioning.
一般认为，原发性全身性癫痫患者认知正常，神经影像学研究结果也正常。我们之前已经表明，青少年肌阵挛性癫痫（JME）患者存在视觉工作记忆受损的情况。在本研究中，我们检测了JME患者在视觉工作记忆范式期间18FDG摄取的相对区域变化。静息状态下，与对照组相比，相对葡萄糖摄取存在区域降低。与对照组受试者不同，在工作记忆任务期间未发现背外侧前额叶皮质活动增加。对照组中摄取增加的其他区域，如运动前皮质和额叶基底皮质，也未出现增加，而颞叶内侧结构似乎在JME中发挥作用，但在对照组受试者的任务表现中并非如此。数据表明，JME作为原发性全身性癫痫的一种类型，可能存在影响致痫潜力和额叶认知功能的皮质结构紊乱。
