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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Buzaleh A M, Batlle A M

Centro de Investigaciones Sobre Porfirinas y Porfirias (CIPYP) (CONICET-FCEN, UBA), Ciudad Universitaria, Pabellón Il, Buenos Aires, Argentina.

Gen Pharmacol. 1996 Sep;27(6):1009-12. doi: 10.1016/0306-3623(95)02137-x.

The influence of strain and sex on the effect of enflurane and isoflurane and administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. 2. Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male. 3. CF1 males showed around 35% decrease in blood PBGase and PBG-deaminase after administration of enflurane, whereas isoflurane provoked a striking inhibition (70%) in males of the C57 strain. 4. Enflurane produced alterations in heme synthesis, which would fit a model of acute porphyria in CF1 male mice. On the other hand, isoflurane would mimic biochemical alterations of this porphyria in C57 males.

研究了应变和性别对恩氟烷和异氟烷作用以及给药对血红素代谢的影响，以确定能最佳重现急性间歇性卟啉症生化体征的动物模型。2. 恩氟烷仅分别使CF1雄性和雌性小鼠的ALA-S活性增加35%和80%，而异氟烷使CF1雄性小鼠的酶活性增加40%。3. 恩氟烷给药后，CF1雄性小鼠的血液PBGase和PBG-脱氨酶降低约35%，而异氟烷对C57品系雄性小鼠产生显著抑制（70%）。4. 恩氟烷引起血红素合成改变，这符合CF1雄性小鼠急性卟啉症模型。另一方面，异氟烷可模拟C57雄性小鼠这种卟啉症的生化改变。

Buzaleh A M, Batlle A M

Centro de Investigaciones Sobre Porfirinas y Porfirias (CIPYP) (CONICET-FCEN, UBA), Ciudad Universitaria, Pabellón Il, Buenos Aires, Argentina.

Gen Pharmacol. 1996 Sep;27(6):1009-12. doi: 10.1016/0306-3623(95)02137-x.

The influence of strain and sex on the effect of enflurane and isoflurane and administration on heme metabolism was investigated to identify the animal model which could best reproduce the biochemical signs of acute intermittent porphyria. 2. Enflurane produced 35% and 80% increases in ALA-S activity only in CF1 male and female mice, respectively, whereas isoflurane induced 40% enzyme activity in CF1 male. 3. CF1 males showed around 35% decrease in blood PBGase and PBG-deaminase after administration of enflurane, whereas isoflurane provoked a striking inhibition (70%) in males of the C57 strain. 4. Enflurane produced alterations in heme synthesis, which would fit a model of acute porphyria in CF1 male mice. On the other hand, isoflurane would mimic biochemical alterations of this porphyria in C57 males.

研究了应变和性别对恩氟烷和异氟烷作用以及给药对血红素代谢的影响，以确定能最佳重现急性间歇性卟啉症生化体征的动物模型。2. 恩氟烷仅分别使CF1雄性和雌性小鼠的ALA-S活性增加35%和80%，而异氟烷使CF1雄性小鼠的酶活性增加40%。3. 恩氟烷给药后，CF1雄性小鼠的血液PBGase和PBG-脱氨酶降低约35%，而异氟烷对C57品系雄性小鼠产生显著抑制（70%）。4. 恩氟烷引起血红素合成改变，这符合CF1雄性小鼠急性卟啉症模型。另一方面，异氟烷可模拟C57雄性小鼠这种卟啉症的生化改变。